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RAT ANTI MOUSE P2X7:FITC Antibody

RAT ANTI MOUSE P2X7:FITC Antibody size: 100ug 343

Supplier MBS MONO
Price 343
Size 100ug
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Also known asP2X7
Other names 7, ATP receptor, ATP receptor, P2X purinoceptor 7, P2X purinoceptor 7, P2X7 purinoceptor, P2X7 receptor, P2Z receptor, P2Z receptor, Purinergic receptor, ligand-gated ion channel, purinergic receptor P2X, P2X purinoceptor 7 isoform a
CategoryAntibodies
SubcategoryMnoclonal antibodies
Gene nameP2X7
Gene name synonimsN/A
Other gene names AI467586, P2X(7), P2X7, P2X7R, P2rx7, P2x7, P2rx7
ClonalityMonoclonal
Immunoglobulin isotypeIgG2b
CloneHano43
Host organismRat (Rattus norvegicus)
Species reactivity Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Mouse (Mus musculus)
Specificity and cross-reactivity As such, It is a cation selective ion channel that opens up on binding of extracellular ATP, Once a pore is opened massive upset of cytoplasmic ion homeostasis occurs and the pore stays open as long as it is bound by ATP, P2X7 blockers might be useful as anti-inflammatory agents, P2X7 plays a key role in the maturation and release of IL-1 and other IL-1 family members during inflammation, Should ATP stimulation continue the cell will become irreversibly damaged and die, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, Sustained activation by extracellular ATP results in the formation of a reversible pore in the plasma membrane that is permeable to hydrophilic solutes of up to 900 Da, The P2X7 ATP receptor has a distinctive long C-terminal tail with multiple potential protein and lipid interaction motifs and is highly polymorphic, This particular antibody might cross react with speacies outside of the listed ones, also known as P2X7, P2X7 This item recognises the P2X purinoceptor 7
Purification methodN/A
Form/AppearanceFITC (Purified IgG conjugated to Fluorescein Isothiocyanate Isomer 1 (FITC) - liquid)
Concentration1 miligram per 1 mililiter, IgG concentration 0
Storage and shipping If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, the antibody is photosensitive and should be protected from light, the antibody should be stored undiluted, Storage in frost-free freezers is not recommended, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term
Tested applications:Flow Cytometry (FACS)
Properties FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, MBS mono FITC is highly sensitive to pH extremes, This MBS mono Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24°
ConjugationAnti-FITC Antibody
Gene targetP2X7:
Short nameRAT ANTI MOUSE P2X7:FITC Antibody
Technique Fluorescein, antibodies against human proteins, antibodies for, Antibody
LabelFITC
Alternative nameRAT antibody to MOUSE P2X7:fluorecein (Antibody to)
Alternative techniqueantibodies
Identity 8537
Gene P2RX7
Long gene name purinergic receptor P2X 7
Synonyms gene name 7 , ligand-gated ion channel, purinergic receptor P2X
Synonyms P2X7 MGC20089
Locus 12q24, 31
Discovery year 1997-10-09
GenBank acession Y09561
Entrez gene record 5027
Pubmed identfication 9038151 9826911
RefSeq identity NM_002562
Classification Purinergic receptors P2X
Havana BLAST/BLAT OTTHUMG00000169153

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