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RAT ANTI MOUSE TIM-3:FITC Antibody

RAT ANTI MOUSE TIM-3:FITC Antibody size: 100ug 448

Supplier MBS MONO
Price 448
Size 100ug
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Also known asTIM-3
Other names HAVcr-2, Hepatitis A virus cellular receptor 2 homolog, T-cell immunoglobulin and mucin domain containing 3, T-cell immunoglobulin and mucin domain-containing protein 3, T-cell immunoglobulin and mucin domain-containing protein 3, T-cell membrane protein 3, T-cell membrane protein 3, TIM-3, TIMD-3, TIMD-3, hepatitis A virus cellular receptor 2, hepatitis A virus cellular receptor 2 homolog, hepatitis A virus cellular receptor 2 homolog
CategoryAntibodies
SubcategoryMnoclonal antibodies
Gene nameTIM-3
Gene name synonimsN/A
Other gene names HAVcr-2, Havcr2, TIM-3, TIMD-3, Tim3, Tim3, Timd3, Timd3, Havcr2
ClonalityMonoclonal
Immunoglobulin isotypeIgG2a
CloneRMT3-23
Host organismRat (Rattus norvegicus)
Species reactivity Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Mouse (Mus musculus)
Specificity and cross-reactivity Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This particular antibody might cross react with speacies outside of the listed ones, Tim-3 is also involved in the regulation of macrophage activation, _x000D__x000D_Studies have shown that clone RMT3-23 significantly inhibits the efficient phagocytosis of apoptotic cells by PEMs (peritoneal exudate Mac1+ cells) _x000D_, _x000D__x000D_Tim-3 acts as a negative regulator of Th1-mediated inflammatory diseases including GVHD, a transmembrane glycoprotein and member of the immunoglobulin superfamily, acts as a phagocytic receptor, and EAE (experimental autoimmune encephamyelitis), and has been shown to recognise apoptotic cells via the IgV domain, and is a receptor for galectin-9, but not by CD4+ Th2 cells or CD8+ Tc2 cells, preferentially expressed by differentiated CD4+ Th1 cells and CD8+ Tc1 (cytotoxic) cells, promotes immunological tolerance, shown to induce cell death of Th1 cells <, specifically recognises mouse T-cell immunoglobulin mucin 3, type I diabetes, /i>, /strong>, Rat anti Mouse Tim-3 clone RMT3-23<, TIM-3 <, i>, in vitro<, strong>
Purification methodN/A
Form/AppearanceFITC (Purified IgG conjugated to Fluorescein Isothiocyanate Isomer 1 (FITC) - liquid)
Concentration1 miligram per 1 mililiter, IgG concentration 0
Storage and shipping If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, the antibody is photosensitive and should be protected from light, the antibody should be stored undiluted, Storage in frost-free freezers is not recommended, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term
Tested applications:Flow Cytometry (FACS)
Properties FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, MBS mono FITC is highly sensitive to pH extremes, This MBS mono Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24°
ConjugationAnti-FITC Antibody
Gene targetTIM-3:
Short nameRAT ANTI MOUSE TIM-3:FITC Antibody
Technique Fluorescein, antibodies against human proteins, antibodies for, Antibody
LabelFITC
Alternative nameRAT antibody to MOUSE TIM-3:fluorecein (Antibody to)
Alternative techniqueantibodies
Identity 18437
Gene HAVCR2
Long gene name hepatitis A virus cellular receptor 2
Synonyms Tim-3 TIM3 FLJ14428 TIMD3 CD366
Synonyms name T-cell immunoglobulin mucin family member 3
Locus 5q33, 3
Discovery year 2002-12-04
GenBank acession AK027334
Entrez gene record 84868
Pubmed identfication 11823861
Classification V-set domain containing
Havana BLAST/BLAT OTTHUMG00000130249

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