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RBCK1 Antibody

RBCK1 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameRBCK1 Primary Polyclonal Antibody
Also known asRBCK1 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenRBCK1
SpecificityThis is a highly specific antibody against RBCK1
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range300-330/510
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human RBCK1/HBV associated factor 4
Gene ID number10616
Swiss ProtQ9BYM8
Tested ApplicationsWB
Recommended dilutionsWB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Binds polyubiquitin of different linkage types, Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation, Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination, LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways, LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex, Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation, Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome, Together with FAM105B/otulin, and then transfers it to substrates, such as UBE2L3/UBCM4, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, E3 ubiquitin-protein ligase
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names C20orf18, HBV-associated factor 4, HOIL-1, HOIL1, Heme-oxidized IRP2 ubiquitin ligase 1, Hepatitis B virus X-associated protein 4, PBMEI, PGBM1, RBCK1, RBCK2, RING finger protein 54, RNF54, RanBP-type and C3HC4-type zinc finger-containing protein 1, UBCE7IP3, Ubiquitin-conjugating enzyme 7-interacting protein 3, XAP4, ZRANB4, XAP3
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetRBCK1
Short nameRBCK1 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameRanBP-classification and C3HC4-classification zinc finger containing 1 (Antibody to)
Alternative techniqueantibodies
Alternative to gene target C20ORF18 and IDBG-641465 and ENSBTAG00000017002 and 504400, C20orf18 and HOIL-1 and HOIL1 and PBMEI and RBCK2 and RNF54 and UBCE7IP3 and XAP3 and XAP4 and ZRANB4, RBCK1 and IDBG-37270 and ENSG00000125826 and 10616, Rbck1 and IDBG-209659 and ENSMUSG00000027466 and 24105, multiple, this GO :0000209 and protein polyubiquitination and biological process this GO :0004842 and ubiquitin-protein transferase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0008270 and zinc ion binding and molecular function this GO :0016032 and viral process and biological process this GO :0016874 and ligase activity and molecular function this GO :0032088 and negative regulation of NF-kappaB transcription factor activity and biological process this GO :0042346 and positive regulation of NF-kappaB import into nucleus and biological process this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043123 and positive regulation of I-kappaB kinase/NF-kappaB signaling and biological process this GO :0043130 and ubiquitin binding and molecular function this GO :0043161 and proteasome-mediated ubiquitin-dependent protein catabolic process and biological process this GO :0045087 and innate immune response and biological process this GO :0050852 and T cell receptor signaling pathway and biological process this GO :0051092 and positive regulation of NF-kappaB transcription factor activity and biological process this GO :0060546 and negative regulation of necroptotic process and biological process this GO :0071797 and LUBAC complex and cellular component this GO :0097039 and protein linear polyubiquitination and biological process this GO :2001238 and positive regulation of extrinsic apoptotic signaling pathway and biological process, this GO :0004842: ubiquitin-protein transferase activity, this GO :0004842: ubiquitin-protein transferase activity and also this GO :0005515: protein binding and also this GO :0008270: zinc ion binding and also this GO :0016874: ligase activity and also this GO :0043130: ubiquitin binding, this GO :0005515: protein binding, this GO :0008270: zinc ion binding, this GO :0016874: ligase activity, this GO :0043130: ubiquitin binding, ubiquitin binding, RanBP-type and C3HC4-type zinc finger containing 1
Identity 15864
Gene RBCK1
Long gene name RANBP2-type and C3HC4-type zinc finger containing 1
Synonyms gene C20orf18
Synonyms gene name chromosome 20 open reading frame 18 RanBP-type and C3HC4-type zinc finger containing 1
Synonyms RBCK2 XAP4 RNF54 ZRANB4 UBCE7IP3 HOIL1
Synonyms name heme-oxidized IRP2 ubiquitin ligase 1
Locus 20p13
Discovery year 2001-06-21
GenBank acession U67322
Entrez gene record 10616
RefSeq identity NM_031229
Classification Ring finger proteins Zinc fingers RANBP2-type Linear ubiquitin chain assembly complex RBR E3 ubiquitin ligases
Havana BLAST/BLAT OTTHUMG00000031634
Locus Specific Databases LRG_728

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