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Recombinant Human Proprotein Convertase Subtilisin, Kexin Type 9, PCSK9 (D374Y, C-6His)

Recombinant Human Proprotein Convertase Subtilisin, Kexin Type 9, PCSK9 (D374Y, C-6His) size: 50 µg 369

Supplier NOVO
Price 369
Size 50 µg
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Reacts withHuman
Source proteins, Recombinants or rec
DescriptionRecombinant Human Proprotein Convertase 9 is produced by our Mammalian expression system and the target gene encoding Gln31-Gln692 is expressed with a 6His tag at the C-terminus
Molecular Weight1 kD, 71
UniProt numberQ8NBP7
State of the productLiquid
Shipping conditionsDry Ice/ice packs
Formulation 150 mM sodium chloride, pH 7, 2 um filtered solution of 50 mM HEPES, 4, Supplied as a 0
Storage recommendations -20°, Please minimize freeze-thaw cycles, stable for 6 months after receipt, C, Store at <
Reconstitution Dissolve the lyophilized protein in ddH2O, Do not mix by vortex or pipetting, It is not recommended to reconstitute to a concentration less than 100 &mu, Please aliquot the reconstituted solution to minimize freeze-thaw cycles, Always centrifuge tubes before opening, g/ml
Purity and determined by Polyacrylamide gel electrophoresis, Greater than 95%
Sequence of the amino acidQEDEDGDYEELVLALRSEEDGLAEAPEHGTTATFHRCAKDPWRLPGTYVVVLKEETHLSQSERTARRLQAQAARRGYLTKILHVFHGLLPGFLVKMSGDLLELALKLPHVDYIEEDSSVFAQSIPWNLERITPPRYRADEYQPPDGGSLVEVYLLDTSIQSDHREIEGRVMVTDFENVPEEDGTRFHRQASKCDSHGTHLAGVVSGRDAGVAKGASMRSLRVLNCQGKGTVSGTLIGLEFIRKSQLVQPVGPLVVLLPLAGGYSRVLNAACQRLARAGVVLVTAAGNFRDDACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGRCVDLFAPGEDIIGASSYCSTCFVSQSGTSQAAAHVAGIAAMMLSAEPELTLAELRQRLIHFSAKDVINEAWFPEDQRVLTPNLVAALPPSTHGAGWQLFCRTVWSAHSGPTRMATAIARCAPDEELLSCSSFSRSGKRRGERMEAQGGKLVCRAHNAFGGEGVYAIARCCLLPQANCSVHTAPPAEASMGTRVHCHQQGHVLTGCSSHWEVEDLGTHKPPVLRPRGQPNQCVGHREASIHASCCHAPGLECKVKEHGIPAPQEQVTVACEEGWTLTGCSALPGTSHVLGAYAVDNTCVVRSRDVSTTGSTSEEAVTAVAICCRSRHLAQASQELQHHHHHH
Levels of endotoxin11 IEU/ug, LAL test shows less than than 0
Properties Depending on the epitopes used human ELISA kits can be cross reactive to many other species, Mainly analyzed are human serum, Modern , cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies, human cell culture supernatants and biological samples, plasma, primarily , saliva, urine,  , (Homo sapiens, Homo sapiens sapiens), Human proteins, humans , ssp
Grouprecombinants
Gene target C-6His), Kexin 9, PCSK9 (D374Y, Proprotein Convertase Subtilisin
Short name C-6His), Kexin 9, PCSK9 (D374Y, Recombinant Proprotein Convertase Subtilisin
Technique E, coli recombinant proteins are , novo advises they will be reconstituted in a buffer soluion or culture medium for cell culture, supplied as white sterile powder lyopillized, Recombinant, genetic recombinations , in Escherichia coli
Species Humans, Human
Alternative name C-6His), Kexin classification 9, proprotein convertase subtilisin/kexin classification 9 (D374Y, sapiens Proprotein Convertase Subtilisin, recombinant H
Alternative techniquerec
Alternative to gene target Extracellular, PCSK9 and IDBG-99082 and ENSG00000169174 and 255738, Pcsk9 and IDBG-170186 and ENSMUSG00000044254 and 100102, this GO :0001822 and kidney development and biological process this GO :0001889 and liver development and biological process this GO :0001920 and negative regulation of receptor recycling and biological process this GO :0002092 and positive regulation of receptor internalization and biological process this GO :0004252 and serine-type endopeptidase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005615 and extracellular space and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005764 and lysosome and cellular component this GO :0005769 and early endosome and cellular component this GO :0005770 and late endosome and cellular component this GO :0005783 and endoplasmic reticulum and cellular component this GO :0005791 and rough endoplasmic reticulum and cellular component this GO :0005794 and this GO lgi apparatus and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006508 and proteolysis and biological process this GO :0006641 and triglyceride metabolic process and biological process this GO :0006644 and phospholipid metabolic process and biological process this GO :0006915 and apoptotic process and biological process this GO :0007041 and lysosomal transport and biological process this GO :0008203 and cholesterol metabolic process and biological process this GO :0009267 and cellular response to starvation and biological process this GO :0009986 and cell surface and cellular component this GO :0010469 and regulation of receptor activity and biological process this GO :0010989 and negative regulation of low-density lipoprotein particle clearance and biological process this GO :0016485 and protein processing and biological process this GO :0016540 and protein autoprocessing and biological process this GO :0019871 and sodium channel inhibitor activity and molecular function this GO :0022008 and neurogenesis and biological process this GO :0030134 and ER to this GO lgi transport vesicle and cellular component this GO :0030169 and low-density lipoprotein particle binding and molecular function this GO :0030182 and neuron differentiation and biological process this GO :0031232 and extrinsic component of external side of plasma membrane and cellular component this GO :0032799 and low-density lipoprotein receptor particle metabolic process and biological process this GO :0032802 and low-density lipoprotein particle receptor catabolic process and biological process this GO :0032803 and regulation of low-density lipoprotein particle receptor catabolic process and biological process this GO :0032869 and cellular response to insulin stimulus and biological process this GO :0034185 and apolipoprotein binding and molecular function this GO :0034189 and very-low-density lipoprotein particle binding and molecular function this GO :0034190 and apolipoprotein receptor binding and molecular function this GO :0042157 and lipoprotein metabolic process and biological process this GO :0042632 and cholesterol homeostasis and biological process this GO :0043523 and regulation of neuron apoptotic process and biological process this GO :0043525 and positive regulation of neuron apoptotic process and biological process this GO :0043621 and protein self-association and molecular function this GO :0044822 and poly(A) RNA binding and molecular function this GO :0048471 and perinuclear region of cytoplasm and cellular component this GO :0050750 and low-density lipoprotein particle receptor binding and molecular function this GO :0070326 and very-low-density lipoprotein particle receptor binding and molecular function, this GO :0004252: serine-type endopeptidase activity, this GO :0004252: serine-type endopeptidase activity and also this GO :0005515: protein binding and also this GO :0019871: sodium channel inhibitor activity and also this GO :0030169: low-density lipoprotein particle binding and also this GO :0034185: apolipoprotein binding and also this GO :0034189: very-low-density lipoprotein particle binding and also this GO :0034190: apolipoprotein receptor binding and also this GO :0043621: protein self-association and also this GO :0044822: poly(A) RNA binding and also this GO :0050750: low-density lipoprotein particle receptor binding and also this GO :0070326: very-low-density lipoprotein particle receptor binding, this GO :0005515: protein binding, this GO :0019871: sodium channel inhibitor activity, this GO :0030169: low-density lipoprotein particle binding, this GO :0034185: apolipoprotein binding, this GO :0034189: very-low-density lipoprotein particle binding, this GO :0034190: apolipoprotein receptor binding, this GO :0043621: protein self-association, this GO :0044822: poly(A) RNA binding, this GO :0050750: low-density lipoprotein particle receptor binding, this GO :0070326: very-low-density lipoprotein particle receptor binding, very-low-density lipoprotein particle receptor binding, proprotein convertase subtilisin/kexin type 9
Identity 20001
Gene PCSK9
Long gene name proprotein convertase subtilisin/kexin type 9
Synonyms gene HCHOLA3
Synonyms gene name autosomal dominant 3 , hypercholesterolemia
Synonyms NARC-1 FH3
Locus 1p32, 3
Discovery year 2003-05-13
GenBank acession AX207686
Entrez gene record 255738
Pubmed identfication 12552133 12730697
RefSeq identity NM_174936
Classification Proprotein convertase subtilisin/kexin family
Havana BLAST/BLAT OTTHUMG00000008136
Locus Specific Databases British Heart Foundation LRG_275

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