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RELB (1684CT450.20.25) Monoclonal Antibody

RELB (1684CT450.20.25) Monoclonal Antibody size: 0.1ml 281

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 281
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name20, 25) Monoclonal Antibody, RELB (1684CT450
Also known as20, 25) Monoclonal Antibody, RELB (1684CT450
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenRELB
SpecificityThis is a highly specific antibody against RELB
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityMonoclonal
Clone number1684CT450, 20, 25
SourceThis RELB antibody is generated from a mouse immunized with a recombinant protein human RELB
Gene ID number5971
Swiss ProtQ01201
Tested ApplicationsWB
Recommended dilutionsWB(1:1000-5000)
Cross reactivity Mouse, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen As a member of the NUPR1/RELB/IER3 survival pathway, Different dimer combinations act as transcriptional activators or repressors, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, In a conventional activation pathway, Increased repression of the heterodimer is seen in the presence of NFKB2/p52, NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family, NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators, NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52, RELB, RELB neither associates with DNA nor with RELA/p65 or REL, Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer in a CRY1/CRY2 independent manner, Stimulates promoter activity in the presence of NFKB2/p49, The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity, cell growth, differentiation, immunity, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, respectively, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus, such as starvation or gemcitabine treatment, tumorigenesis and apoptosis, NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation
Purification methodPurified by Protein G
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names I-REL, REL-B, RELB, Transcription factor RelB, IREL
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
About Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones
Gene target20, 25) Monoclonal, RELB (1684CT450
Short name20, 25) Monoclonal Antibody, RELB (1684CT450
Technique Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody
Alternative name20, 25) monoclonal (Antibody to), v-v-rel reticuloendotheliosis viral oncogene homolog (avian) reticuloendotheliosis viral oncogene homolog B (1684CT450
Alternative techniqueantibodies
Alternative to gene target DNA-templated and biological process this GO :0006355 and regulation of transcription, DNA-templated and biological process this GO :0010628 and positive regulation of gene expression and biological process this GO :0019882 and antigen processing and presentation and biological process this GO :0032922 and circadian regulation of gene expression and biological process this GO :0038061 and NIK/NF-kappaB signaling and biological process this GO :0042088 and T-helper 1 type immune response and biological process this GO :0043011 and myeloid dendritic cell differentiation and biological process this GO :0045063 and T-helper 1 cell differentiation and biological process this GO :0045087 and innate immune response and biological process this GO :0071470 and cellular response to osmotic stress and biological process, I-REL and IREL and REL-B, RELB and IDBG-57021 and ENSG00000104856 and 5971, RELB and IDBG-639330 and ENSBTAG00000038428 and 522670, Relb and IDBG-151419 and ENSMUSG00000002983 and 19698, nuclei, protein binding, this GO :0001047 and core promoter binding and molecular function this GO :0003677 and DNA binding and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0003714 and transcription corepressor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005815 and microtubule organizing center and cellular component this GO :0005829 and cytosol and cellular component this GO :0006351 and transcription, this GO :0001047: core promoter binding, this GO :0001047: core promoter binding and also this GO :0003677: DNA binding and also this GO :0003700: sequence-specific DNA binding transcription factor activity and also this GO :0003714: transcription corepressor activity and also this GO :0005515: protein binding, this GO :0003677: DNA binding, this GO :0003700: sequence-specific DNA binding transcription factor activity, this GO :0003714: transcription corepressor activity, this GO :0005515: protein binding, v-rel reticuloendotheliosis viral oncogene homolog B
Identity 9956
Gene RELB
Long gene name NF-kB subunit , RELB proto-oncogene
Synonyms gene name v-rel avian reticuloendotheliosis viral oncogene homolog B (nuclear factor of kappa light polypeptide gene enhancer in B-cells 3)
Synonyms REL-B
Locus 19q13, 32
Discovery year 1995-10-02
GenBank acession M83221
Entrez gene record 5971
Pubmed identfication 1531086
Classification NF-kappa B complex subunits
Havana BLAST/BLAT OTTHUMG00000162116

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