| Long name | 2, 3) Monoclonal Antibody, RET (188CT11 |
| Also known as | 2, 3) Monoclonal Antibody, RET (188CT11 |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | RET |
| Specificity | This is a highly specific antibody against RET |
| Modification(s) | None |
| Modification site(s) | Unmodified antibody |
| Clonality | Monoclonal |
| Clone number | 188CT11, 2, 3 |
| Source | This RET Monoclonal antibody was raised using purified His-tagged recombinant human RET |
| Gene ID number | 5979 |
| Swiss Prot | P07949 |
| Tested Applications | IF, IHC-P, WB |
| Recommended dilutions | IHC-P(1:50~100), IF(1:10~50), WB(1:500~16000) |
| Cross reactivity | Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | Active in the absence of ligand, Acts as a dependence receptor, ITGB1 and ITGB3)-dependent manner, Involved in the development of the neural crest, Mediator of several diseases such as neuroendocrine cancers, Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e, Phosphorylates PTK2/FAK1, Regulates both cell death/survival balance and positional information, Regulates nociceptor survival and size, Required for the molecular mechanisms orchestration during intestine organogenesis, Triggers the differentiation of rapidly adapting (RA) mechanoreceptors, a major component of the gut-associated lymphoid tissue, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands, and promotes the formation of Peyer's patch-like structures, but triggers apoptosis in absence of GDNF, cell migration, in the presence of the ligand GDNF in somatotrophs (within pituitary), involved in the development of enteric nervous system and renal organogenesis during embryonic life, neuronal navigation, promotes survival and down regulates growth hormone (GH) production, these diseases are characterized by aberrant integrins-regulated cell migration, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage, Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, g |
| Purification method | 09% (W/V) sodium azide, Mouse monoclonal antibody supplied in crude ascites with 0 |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | CDHF12, CDHR16, Cadherin family member 12, HSCR1, MEN2A, MEN2B, MTC1, Proto-oncogene c-Ret, Proto-oncogene tyrosine-protein kinase receptor Ret, RET, RET-ELE1, RET51, PTC |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About | Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target | 2, 3) Monoclonal, RET (188CT11 |
| Short name | 2, 3) Monoclonal Antibody, RET (188CT11 |
| Technique | Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name | 2, 3) monoclonal (Antibody to), ret proto-oncogene (188CT11 |
| Alternative technique | antibodies |
| Alternative to gene target | CDHF12 and CDHR16 and HSCR1 and MEN2A and MEN2B and MTC1 and PTC and RET-ELE1 and RET51, DNA-templated and biological process this GO :0048265 and response to pain and biological process this GO :0048484 and enteric nervous system development and biological process this GO :0050770 and regulation of axonogenesis and biological process this GO :0060041 and retina development in camera-type eye and biological process this GO :0060384 and innervation and biological process this GO :0061146 and Peyer's patch morphogenesis and biological process this GO :0071300 and cellular response to retinoic acid and biological process this GO :0072300 and positive regulation of metanephric glomerulus development and biological process this GO :0097021 and lymphocyte migration into lymphoid organs and biological process this GO :2001241 and positive regulation of extrinsic apoptotic signaling pathway in absence of ligand and biological process, Plasma membranes, RET and IDBG-628722 and ENSBTAG00000000570 and 515924, RET and IDBG-71064 and ENSG00000165731 and 5979, Ret and IDBG-181393 and ENSMUSG00000030110 and 19713, this GO :0000165 and MAPK cascade and biological process this GO :0001657 and ureteric bud development and biological process this GO :0001755 and neural crest cell migration and biological process this GO :0001838 and embryonic epithelial tube formation and biological process this GO :0004672 and protein kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0004714 and transmembrane receptor protein tyrosine kinase activity and molecular function this GO :0004872 and receptor activity and molecular function this GO :0005509 and calcium ion binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006919 and activation of cysteine-type endopeptidase activity involved in apoptotic process and biological process this GO :0007156 and homophilic cell adhesion and biological process this GO :0007158 and neuron cell-cell adhesion and biological process this GO :0007165 and signal transduction and biological process this GO :0007169 and transmembrane receptor protein tyrosine kinase signaling pathway and biological process this GO :0007399 and nervous system development and biological process this GO :0007497 and posterior midgut development and biological process this GO :0010008 and endosome membrane and cellular component this GO :0010976 and positive regulation of neuron projection development and biological process this GO :0014042 and positive regulation of neuron maturation and biological process this GO :0016020 and membrane and cellular component this GO :0016772 and transferase activity, this GO :0004672: protein kinase activity, this GO :0004672: protein kinase activity and also this GO :0004713: protein tyrosine kinase activity and also this GO :0004714: transmembrane receptor protein tyrosine kinase activity and also this GO :0004872: receptor activity and also this GO :0005509: calcium ion binding and also this GO :0005515: protein binding and also this GO :0005524: ATP binding and also this GO :0016772: transferase activity, this GO :0004713: protein tyrosine kinase activity, this GO :0004714: transmembrane receptor protein tyrosine kinase activity, this GO :0004872: receptor activity, this GO :0005509: calcium ion binding, this GO :0005515: protein binding, this GO :0005524: ATP binding, this GO :0016772: transferase activity, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups, transferring phosphorus-containing groups and molecular function this GO :0018108 and peptidyl-tyrosine phosphorylation and biological process this GO :0030155 and regulation of cell adhesion and biological process this GO :0030182 and neuron differentiation and biological process this GO :0030335 and positive regulation of cell migration and biological process this GO :0033619 and membrane protein proteolysis and biological process this GO :0033630 and positive regulation of cell adhesion mediated by integrin and biological process this GO :0035799 and ureter maturation and biological process this GO :0042493 and response to drug and biological process this GO :0042551 and neuron maturation and biological process this GO :0043235 and receptor complex and cellular component this GO :0045121 and membrane raft and cellular component this GO :0045793 and positive regulation of cell size and biological process this GO :0045893 and positive regulation of transcription, ret proto-oncogene |
| Identity | 9967 |
| Gene | RET |
| Long gene name | ret proto-oncogene |
| Synonyms gene | HSCR1 MEN2A MTC1 MEN2B |
| Synonyms gene name | multiple endocrine neoplasia and medullary thyroid carcinoma 1 Hirschsprung disease 1 |
| Synonyms | PTC CDHF12 RET51 CDHR16 |
| Synonyms name | cadherin-related family member 16 RET receptor tyrosine kinase rearranged during transfection |
| Locus | 10q11, 21 |
| Discovery year | 1990-07-15 |
| GenBank acession | BC004257 |
| Entrez gene record | 5979 |
| Pubmed identfication | 2687772 1611909 |
| RefSeq identity | NM_020975 |
| Classification | Cadherin related Receptor Tyrosine Kinases |
| Havana BLAST/BLAT | OTTHUMG00000018024 |
| Locus Specific Databases | LRG_518 |
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