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RIM2 Antibody

RIM2 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameRIM2 Primary Polyclonal Antibody
Also known asRIM2 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenRIM2
SpecificityThis is a highly specific antibody against RIM2
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human RIM2
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Both Rim1 and Rim2 can bind to cAMP-GEFII, PKA-dependent exocytosis (3), Rab3 binding domain of Rim enhances glucose-stimulated secretion in intact cells and Ca2+-stimulated exocytosis in permeabilized cells, Rab3 functions in an inhibitory capacity by controlling the recruitment of secretory vesicles into a releasable pool at the plasma membrane, Rim (rab3 interacting molecule), Rim also localizes on the plasma membrane of INS-1E cells and pancreatic beta-cells, Rim exists as two variants, Rim serves as a Rab3-dependent regulator of synaptic-vesicle fusion by forming a GTP-dependent complex between synaptic plasma membranes and docked synaptic vesicles (5), Rim1 and Rim2, Rim1 is expressed near the active zone at the synapse, Therefore, a neural/neuroendocrine-specific member of the Rab family, a putative effector protein for Rab3s, is composed of an amino-terminal zinc-finger motif and carboxy-terminal PDZ and C2 domains, is involved in Ca2+-regulated exocytosis (1-2), located on synaptic vesicles (4), produced by alternative splicing (3), suggesting that Rim may also play a regulatory role in insulin secretion (6), where it interacts in a GTP-dependent manner with Rab3, which is a direct target of cAMP in regulated exocytosis and is responsible for cAMP-dependent, Rab3
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names RAB3IP3, RIMS2_HUMAN, Rab3 interacting molecule 2, Regulating synaptic membrane exocytosis protein 2, Rims2, Non small cell lung cancer RimL3a protein
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetRIM2
Short nameRIM2 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameRIM2 (Antibody to)
Alternative techniqueantibodies
Identity 17283
Gene RIMS2
Long gene name regulating synaptic membrane exocytosis 2
Synonyms gene RAB3IP3
Synonyms gene name RAB3 interacting protein 3
Synonyms KIAA0751 RIM2 OBOE
Locus 8q22, 3
Discovery year 2002-04-29
GenBank acession AB018294
Entrez gene record 9699
Pubmed identfication 9872452 12578829
RefSeq identity NM_001100117
Classification Regulating synaptic membrane exocytosis family PDZ domain containing
Havana BLAST/BLAT OTTHUMG00000162097

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