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RIM2 Antibody, ALEXA FLUOR 555

RIM2 Antibody, ALEXA FLUOR 555 size: 100ul 332

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES
Price 332
Size 100ul
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name ALEXA FLUOR 555 Conjugated, RIM2 Polyclonal Antibody
Also known asAnti-RIM2 PAb ALEXA FLUOR 555
CategoryConjugated Primary Antibodies
Conjugated with 555, ALEXA FLUOR®
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenRIM2
SpecificityThis is a highly specific antibody against RIM2
ModificationUnmodified
Modification SiteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human RIM2
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Cross-reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen Both Rim1 and Rim2 can bind to cAMP-GEFII, PKA-dependent exocytosis (3), Rab3 binding domain of Rim enhances glucose-stimulated secretion in intact cells and Ca2+-stimulated exocytosis in permeabilized cells, Rab3 functions in an inhibitory capacity by controlling the recruitment of secretory vesicles into a releasable pool at the plasma membrane, Rim (rab3 interacting molecule), Rim also localizes on the plasma membrane of INS-1E cells and pancreatic beta-cells, Rim exists as two variants, Rim serves as a Rab3-dependent regulator of synaptic-vesicle fusion by forming a GTP-dependent complex between synaptic plasma membranes and docked synaptic vesicles (5), Rim1 and Rim2, Rim1 is expressed near the active zone at the synapse, Therefore, a neural/neuroendocrine-specific member of the Rab family, a putative effector protein for Rab3s, is composed of an amino-terminal zinc-finger motif and carboxy-terminal PDZ and C2 domains, is involved in Ca2+-regulated exocytosis (1-2), located on synaptic vesicles (4), produced by alternative splicing (3), suggesting that Rim may also play a regulatory role in insulin secretion (6), where it interacts in a GTP-dependent manner with Rab3, which is a direct target of cAMP in regulated exocytosis and is responsible for cAMP-dependent, Rab3
PurificationPurified by Protein A
Storage conditions 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission553nm/568nm
Synonyms KIAA0751 RIM2 OBOE
Properties ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, Very high photo stable ALEXA conjugate, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation ALEXA FLUOR 555, Alexa Fluor
Gene targetRIM2
Short nameRIM2 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
LabelALEXA FLUOR 555
Alternative name ALEXA FLUOR 555, RIM2 (Antibody to)
Alternative techniqueantibodies
Identity 17283
Gene RIMS2
Long gene name regulating synaptic membrane exocytosis 2
Synonyms gene RAB3IP3
Synonyms gene name RAB3 interacting protein 3
Locus 8q22, 3
Discovery year 2002-04-29
GenBank acession AB018294
Entrez gene record 9699
Pubmed identfication 9872452 12578829
RefSeq identity NM_001100117
Classification Regulating synaptic membrane exocytosis family PDZ domain containing
Havana BLAST/BLAT OTTHUMG00000162097

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