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RIM2 Antibody, Biotin Conjugated

RIM2 Antibody, Biotin Conjugated size: 0.1ml 333

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 333
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Biotin Conjugated, RIM2 Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationBiotinylated
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenRIM2
SpecificityThis is a highly specific antibody against RIM2
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
SourceKLH conjugated synthetic peptide derived from human RIM2
Tested applications IHC-P, WB
Recommended dilutions IHC-P(1:100-500), WB(1:100-1000)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Both Rim1 and Rim2 can bind to cAMP-GEFII, PKA-dependent exocytosis (3), Rab3 binding domain of Rim enhances glucose-stimulated secretion in intact cells and Ca2+-stimulated exocytosis in permeabilized cells, Rab3 functions in an inhibitory capacity by controlling the recruitment of secretory vesicles into a releasable pool at the plasma membrane, Rim (rab3 interacting molecule), Rim also localizes on the plasma membrane of INS-1E cells and pancreatic beta-cells, Rim exists as two variants, Rim serves as a Rab3-dependent regulator of synaptic-vesicle fusion by forming a GTP-dependent complex between synaptic plasma membranes and docked synaptic vesicles (5), Rim1 and Rim2, Rim1 is expressed near the active zone at the synapse, Therefore, a neural/neuroendocrine-specific member of the Rab family, a putative effector protein for Rab3s, is composed of an amino-terminal zinc-finger motif and carboxy-terminal PDZ and C2 domains, is involved in Ca2+-regulated exocytosis (1-2), located on synaptic vesicles (4), produced by alternative splicing (3), suggesting that Rim may also play a regulatory role in insulin secretion (6), where it interacts in a GTP-dependent manner with Rab3, which is a direct target of cAMP in regulated exocytosis and is responsible for cAMP-dependent, Rab3
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation EmissionN/A
Synonyms KIAA0751 RIM2 OBOE
Properties Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetRIM2 Conjugated
Short name Conjugated, RIM2 Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelBiotin
Alternative name biotinilated coupled, RIM2 (Antibody to)
Alternative techniqueantibodies
Identity 17283
Gene RIMS2
Long gene name regulating synaptic membrane exocytosis 2
Synonyms gene RAB3IP3
Synonyms gene name RAB3 interacting protein 3
Locus 8q22, 3
Discovery year 2002-04-29
GenBank acession AB018294
Entrez gene record 9699
Pubmed identfication 9872452 12578829
RefSeq identity NM_001100117
Classification Regulating synaptic membrane exocytosis family PDZ domain containing
Havana BLAST/BLAT OTTHUMG00000162097

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