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RIM2 Antibody, Cy5.5 Conjugated

RIM2 Antibody, Cy5.5 Conjugated size: 0.1ml 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 350
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Cy5, 5 Conjugated, RIM2 Polyclonal Antibody
CategoryConjugated Primary Antibodies
Conjugation Cy5, 5, 5, Cy5
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenRIM2
SpecificityThis is a highly specific antibody against RIM2
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
SourceKLH conjugated synthetic peptide derived from human RIM2
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Both Rim1 and Rim2 can bind to cAMP-GEFII, PKA-dependent exocytosis (3), Rab3 binding domain of Rim enhances glucose-stimulated secretion in intact cells and Ca2+-stimulated exocytosis in permeabilized cells, Rab3 functions in an inhibitory capacity by controlling the recruitment of secretory vesicles into a releasable pool at the plasma membrane, Rim (rab3 interacting molecule), Rim also localizes on the plasma membrane of INS-1E cells and pancreatic beta-cells, Rim exists as two variants, Rim serves as a Rab3-dependent regulator of synaptic-vesicle fusion by forming a GTP-dependent complex between synaptic plasma membranes and docked synaptic vesicles (5), Rim1 and Rim2, Rim1 is expressed near the active zone at the synapse, Therefore, a neural/neuroendocrine-specific member of the Rab family, a putative effector protein for Rab3s, is composed of an amino-terminal zinc-finger motif and carboxy-terminal PDZ and C2 domains, is involved in Ca2+-regulated exocytosis (1-2), located on synaptic vesicles (4), produced by alternative splicing (3), suggesting that Rim may also play a regulatory role in insulin secretion (6), where it interacts in a GTP-dependent manner with Rab3, which is a direct target of cAMP in regulated exocytosis and is responsible for cAMP-dependent, Rab3
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission675nm/694nm
Synonyms KIAA0751 RIM2 OBOE
Properties Cy5 antibodies are excited by the 650-nanometer wave of an argon laser and detected at a 670-nanometer captor, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
ConjugatedThese antibodies are excite for emission at 678nm and detected at a 694 , nm wavelengths
Gene targetRIM2 Conjugated
Short name Conjugated, RIM2 Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
Label5, Cy5
Alternative name cyanine 5, 5 coupled, RIM2 (Antibody to)
Alternative techniqueantibodies
Identity 17283
Gene RIMS2
Long gene name regulating synaptic membrane exocytosis 2
Synonyms gene RAB3IP3
Synonyms gene name RAB3 interacting protein 3
Locus 8q22, 3
Discovery year 2002-04-29
GenBank acession AB018294
Entrez gene record 9699
Pubmed identfication 9872452 12578829
RefSeq identity NM_001100117
Classification Regulating synaptic membrane exocytosis family PDZ domain containing
Havana BLAST/BLAT OTTHUMG00000162097

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