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RIP1 (7H10) Monoclonal Antibody

RIP1 (7H10) Monoclonal Antibody size: 0.1ml 362

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 362
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameRIP1 (7H10) Monoclonal Antibody
Also known asRIP1 (7H10) Monoclonal Antibody
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenRIP1
SpecificityThis is a highly specific antibody against RIP1
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityMonoclonal
Clone number7H10
Concentration1ug per 1ul
SourceRecombinant human protein purified from E, coli (His/ABD-RIP1)
Gene ID number8737
Swiss ProtQ13546
Tested Applications IP, WB
Recommended dilutions000) IP (2 ul), WB (1:500~1:2
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death, Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, Polyubiquitinated protein binds to IKBKG/NEMO, RIPK1 and RIPK3 association, TRADD and TRAF2 are recruited to the receptor, Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, Upon activation of TNFR1 by the TNF-alpha family cytokines, a critical event for NF-kappa-B activation, activation of pathogen recognition receptors (PRRs), and DNA damage, and thereby activates the MAP3K5-JNK apoptotic cascade, forms a necrosis-inducing complex, in particular, the regulatory subunit of the IKK complex, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules, Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation
Purification methodPurified by Protein G
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names Cell death protein RIP, RIP-1, RIP1, RIPK1, Receptor-interacting protein 1, Receptor-interacting serine/threonine-protein kinase 1, Serine/threonine-protein kinase RIP, RIP
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
About Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones
Gene targetRIP1 (7H10) Monoclonal
Short nameRIP1 (7H10) Monoclonal Antibody
Technique Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody
Alternative nameRIP1 (7H10) monoclonal (Antibody to)
Alternative techniqueantibodies
Identity 9841
Gene RALBP1
Long gene name ralA binding protein 1
Synonyms RLIP76 RIP1 RIP
Locus 18p11, 22
Discovery year 2000-02-11
GenBank acession L42542
Entrez gene record 10928
Pubmed identfication 7673236
RefSeq identity NM_006788
Havana BLAST/BLAT OTTHUMG00000131596

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