| Long name | RIT1 Primary Polyclonal Antibody |
| Also known as | RIT1 PAb |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | RIT1 |
| Specificity | This is a highly specific antibody against RIT1 |
| Modification(s) | None |
| Modification site(s) | Unmodified antibody |
| Clonality | Polyclonal antibody |
| Clone number | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Source | This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human RIT1 |
| Gene ID number | 6016 |
| Tested Applications | IF(IHC-P), IHC-P, WB |
| Recommended dilutions | IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity | Mouse, Rat, Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | Calmodulin is a primary mediator of Ca2+ signals in the nervous system, In addition, In conclusion, Ric, Rin and Rit (Ric-related gene expressed in many tissues), Rin binds calmodulin through a C-terminal binding motif, Rit and Ric are widely expressed, Rit and Rin define a novel subfamily of Ras-related proteins, Rit and Rin lack the recognition signal for C-terminal prenylation, Transiently expressed Rit and Rin are plasma membrane-localized because both proteins contain a C-terminal cluster of basic amino acids, While most members of the Ras subfamily are plasma membrane-associated and generally require a C-terminal isoprenyl group to bind to the plasma membrane, a protein related to the Ras subfamily of small GTPases, has the ability to bind calmodulin, share related G2 domains with Ric, two Ras-like human proteins, whereas expression of Rin is restricted to the neuron system, which are 71% and 66% identical to RIC respectively, which provides a mechanism for membrane association, which then serves as a second messenger to direct diverse cellular responses, Neuronal activity dramatically increases the concentration of cytosolic Ca2+, Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation |
| Purification method | This antibody was purified via Protein A |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | GTP-binding protein Rit1, RIBB, RIT, RIT1, RIT1_HUMAN, ROC1, Ras like protein expressed in many tissues, Ras like without CAAX 1, Ras-like protein expressed in many tissues, Ras-like without CAAX protein 1, Ric like expressed in many tissues, GTP binding protein Roc1 |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target | RIT1 |
| Short name | RIT1 Antibody |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Alternative name | RIT1 (Antibody to) |
| Alternative technique | antibodies |
| Identity | 10023 |
| Gene | RIT1 |
| Long gene name | Ras like without CAAX 1 |
| Synonyms gene | RIT |
| Synonyms gene name | Ric (Drosophila)-like, expressed in many tissues |
| Synonyms | RIBB ROC1 MGC125864 MGC125865 |
| Synonyms name | Ric-like, expressed in many tissues GTP-binding protein Roc1 |
| Locus | 1q22 |
| Discovery year | 1996-08-28 |
| GenBank acession | AF084462 |
| Entrez gene record | 6016 |
| Pubmed identfication | 8824319 8918462 |
| RefSeq identity | NM_006912 |
| Classification | RAS type GTPase family |
| Havana BLAST/BLAT | OTTHUMG00000014104 |
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