Name : RNF31 Antibody, ALEXA FLUOR 488
Supplier : BIOSS PRIMARY CONJUGATED ANTIBODIES
Price :332
SKU : GEN8321109095
| Long name | ALEXA FLUOR 488 Conjugated, RNF31 Polyclonal Antibody |
| Also known as | Anti-RNF31 PAb ALEXA FLUOR 488 |
| Category | Conjugated Primary Antibodies |
| Conjugated with | 488, ALEXA FLUOR® |
| Host Organism | Rabbit (Oryctolagus cuniculus) |
| Target Antigen | RNF31 |
| Specificity | This is a highly specific antibody against RNF31 |
| Modification | Unmodified |
| Modification Site | None |
| Clonality | Polyclonal |
| Clone | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Subcellular location | Cytoplasm |
| Source | This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human RNF31 |
| Gene ID Number | 55072 |
| Swiss Prot | Q96EP0 |
| Tested applications | IF(IHC-P) |
| Recommended dilutions | IF(IHC-P)(1:50-200) |
| Crossreactivity | Mouse, Rat, Human |
| Cross-reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen | Binds polyubiquitin of different linkage types, LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways, LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex, Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation, Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis, E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation |
| Purification | Purified by Protein A |
| Storage conditions | 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission | 499nm/519nm |
| Synonyms | ZIBRA FLJ10111 FLJ23501 HOIP Paul |
| Properties | ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the RNF31 Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation | Alexa Fluor |
| Gene target | RNF31 |
| Short name | RNF31 Antibody |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Label | ALEXA FLUOR 488 |
| Alternative name | ALEXA FLUOR 488, E3 ubiquitin-protein ligase RNF31 (Antibody to) |
| Alternative technique | antibodies |
| Alternative to gene target | IRF-9 and ISGF3 and ISGF3G and p48, RNF31 and IDBG-544948 and ENSG00000259529 and 10379, multiple, this GO :0004842 and ubiquitin-protein transferase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0008270 and zinc ion binding and molecular function this GO :0016567 and protein ubiquitination and biological process this GO :0071797 and LUBAC complex and cellular component, this GO :0004842: ubiquitin-protein transferase activity, this GO :0004842: ubiquitin-protein transferase activity and also this GO :0005515: protein binding and also this GO :0008270: zinc ion binding, this GO :0005515: protein binding, this GO :0008270: zinc ion binding, zinc ion binding, E3 ubiquitin-protein ligase RNF31 |
| Identity | 16031 |
| Gene | RNF31 |
| Long gene name | ring finger protein 31 |
| Synonyms name | HOIL-1-interacting protein |
| Locus | 14q12 |
| Discovery year | 2003-09-29 |
| GenBank acession | AK000973 |
| Entrez gene record | 55072 |
| Pubmed identfication | 10422847 |
| RefSeq identity | NM_017999 |
| Classification | Zinc fingers RANBP2-type Ring finger proteins Linear ubiquitin chain assembly complex RBR E3 ubiquitin ligases |
| Havana BLAST/BLAT | OTTHUMG00000028798 |