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RPA2(Thr21) Antibody

RPA2(Thr21) Antibody size: 0.1ml 281

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 281
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameRPA2(Thr21) Primary Polyclonal Antibody
Also known asRPA2(Thr21) PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenRPA2Thr21
SpecificityThis is a highly specific antibody against RPA2Thr21
Modification(s)Phosphorylation
Modification site(s)Thr21
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range5-40/270
Subcellular locationNucleus
SourceKLH conjugated synthetic phosphopeptide derived from human RPA2 around the phosphorylation site of Thr21
Gene ID number6118
Swiss ProtP15927
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Also recruits SMARCAL1/HARP, Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair, In the cellular response to DNA damage, It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage, It prevents their reannealing and in parallel, May also play a role in telomere maintenance, Plays also a role in base excision repair (BER) probably through interaction with UNG, Thereby, Through RFWD3 may activate CHEK1 and play a role in replication checkpoint control, Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response, binds and stabilizes single-stranded DNA intermediates, it plays an essential role both in DNA replication and the cellular response to DNA damage, recruits and activates different proteins and complexes involved in DNA metabolism, that form during DNA replication or upon DNA stress, the RPA complex controls DNA repair and DNA damage checkpoint activation, to sites of DNA damage, which is involved in replication fork restart, As part of the heterotrimeric replication protein A complex (RPA/RP-A)
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names RF-A protein 2, RP-A p32, RP-A p34, RPA2, RPA32, RPA34, Replication factor A protein 2, Replication protein A 32 kDa subunit, Replication protein A 34 kDa subunit, REPA2
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetRPA2(Thr21)
Short nameRPA2(Thr21) Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameRPA2(Thr21) (Antibody to)
Alternative techniqueantibodies
Identity 10290
Gene RPA2
Long gene name replication protein A2
Synonyms gene name 32kDa , replication protein A2 (32kD) replication protein A2
Locus 1p35, 3
Discovery year 1993-12-14
GenBank acession BC021257
Entrez gene record 6118
Pubmed identfication 8454588
RefSeq identity NM_002946
Classification Nucleotide excision repair
Havana BLAST/BLAT OTTHUMG00000003915

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