| Long name | RPS3 Primary Polyclonal Antibody |
| Also known as | RPS3 PAb |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | RPS3 |
| Specificity | This is a highly specific antibody against RPS3 |
| Modification(s) | None |
| Modification site(s) | Unmodified antibody |
| Clonality | Polyclonal antibody |
| Clone number | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Immunogen range | 135-170/243 |
| Subcellular location | Mitochondrion, Nucleus, Cytoplasm |
| Source | This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human RPS3 |
| Gene ID number | 6188 |
| Swiss Prot | P23396 |
| Tested Applications | IF(IHC-P), IHC-P, WB |
| Recommended dilutions | IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity | Mouse, Rat, Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | Also stimulates the cleavage of the phosphodiester backbone by APEX1 (PubMed:18973764), Binds to and protects TP53/p53 from MDM2-mediated ubiquitination (PubMed:19656744), Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (PubMed:15707971), Displays high binding affinity for 7, Enhances the uracil excision activity of UNG1 (PubMed:18973764), Has also been shown to bind with similar affinity to intact and damaged DNA (PubMed:18610840), Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide (PubMed:17049931), Has endonuclease activity and plays a role in repair of damaged DNA (PubMed:7775413), Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5 (PubMed:20605787), Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation (PubMed:22510408), Involved in induction of apoptosis through its role in activation of CASP8 (PubMed:14988002), Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization (PubMed:23131551), Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, Represses its own translation by binding to its cognate mRNA (PubMed:20217897), Stimulates the N-glycosylase activity of the base excision protein OGG1 (PubMed:15518571), When located in the mitochondrion, a common DNA lesion caused by reactive oxygen species (ROS) (PubMed:14706345), enhances binding of the complex to DNA and promotes transcription of target genes (PubMed:18045535), reduces cellular ROS levels and mitochondrial DNA damage (PubMed:23911537), 8-dihydro-8-oxoguanine (8-oxoG), Involved in translation as a component of the 40S small ribosomal subunit (PubMed:8706699) |
| Purification method | This antibody was purified via Protein A |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | 40S ribosomal protein S3, OK/SW-cl, RPS3, 26, S3 |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target | RPS3 |
| Short name | RPS3 Antibody |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Alternative name | ribosomal protein S3 (Antibody to) |
| Alternative technique | antibodies |
| Alternative to gene target | RPS3 and IDBG-635601 and ENSBTAG00000005620 and 326588, RPS3 and IDBG-64727 and ENSG00000149273 and 6188, Rps3 and IDBG-200714 and ENSMUSG00000030744 and 27050, S3, endonucleolytic and biological process this GO :0002181 and cytoplasmic translation and biological process this GO :0003684 and damaged DNA binding and molecular function this GO :0003723 and RNA binding and molecular function this GO :0003729 and mRNA binding and molecular function this GO :0003735 and structural constituent of ribosome and molecular function this GO :0003906 and DNA-(apurinic or apyrimidinic site) lyase activity and molecular function this GO :0004519 and endonuclease activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0005840 and ribosome and cellular component this GO :0006412 and translation and biological process this GO :0006413 and translational initiation and biological process this GO :0006414 and translational elongation and biological process this GO :0006415 and translational termination and biological process this GO :0006614 and SRP-dependent cotranslational protein targeting to membrane and biological process this GO :0006974 and cellular response to DNA damage stimulus and biological process this GO :0010467 and gene expression and biological process this GO :0015935 and small ribosomal subunit and cellular component this GO :0016020 and membrane and cellular component this GO :0016032 and viral process and biological process this GO :0016070 and RNA metabolic process and biological process this GO :0016071 and mRNA metabolic process and biological process this GO :0019058 and viral life cycle and biological process this GO :0019083 and viral transcription and biological process this GO :0019899 and enzyme binding and molecular function this GO :0019901 and protein kinase binding and molecular function this GO :0022627 and cytosolic small ribosomal subunit and cellular component this GO :0030529 and ribonucleoprotein complex and cellular component this GO :0032587 and ruffle membrane and cellular component this GO :0044267 and cellular protein metabolic process and biological process this GO :0044822 and poly(A) RNA binding and molecular function this GO :0045738 and negative regulation of DNA repair and biological process this GO :0051018 and protein kinase A binding and molecular function this GO :0051059 and NF-kappaB binding and molecular function this GO :0051092 and positive regulation of NF-kappaB transcription factor activity and biological process this GO :0051536 and iron-sulfur cluster binding and molecular function this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0071159 and NF-kappaB complex and cellular component this GO :0090305 and nucleic acid phosphodiester bond hydrolysis and biological process this GO :1902546 and positive regulation of DNA N-glycosylase activity and biological process this GO :2001235 and positive regulation of apoptotic signaling pathway and biological process, iron-sulfur cluster binding, nonsense-mediated decay and biological process this GO :0000737 and DNA catabolic process, nuclei, this GO :0000184 and nuclear-transcribed mRNA catabolic process, this GO :0003684: damaged DNA binding, this GO :0003684: damaged DNA binding and also this GO :0003723: RNA binding and also this GO :0003729: mRNA binding and also this GO :0003735: structural constituent of ribosome and also this GO :0003906: DNA-(apurinic or apyrimidinic site) lyase activity and also this GO :0004519: endonuclease activity and also this GO :0005515: protein binding and also this GO :0019899: enzyme binding and also this GO :0019901: protein kinase binding and also this GO :0044822: poly(A) RNA binding and also this GO :0051018: protein kinase A binding and also this GO :0051059: NF-kappaB binding and also this GO :0051536: iron-sulfur cluster binding, this GO :0003723: RNA binding, this GO :0003729: mRNA binding, this GO :0003735: structural constituent of ribosome, this GO :0003906: DNA-(apurinic or apyrimidinic site) lyase activity, this GO :0004519: endonuclease activity, this GO :0005515: protein binding, this GO :0019899: enzyme binding, this GO :0019901: protein kinase binding, this GO :0044822: poly(A) RNA binding, this GO :0051018: protein kinase A binding, this GO :0051059: NF-kappaB binding, this GO :0051536: iron-sulfur cluster binding, ribosomal protein S3 |
| Identity | 10420 |
| Gene | RPS3 |
| Long gene name | ribosomal protein S3 |
| Synonyms | FLJ26283 FLJ27450 MGC87870 S3 |
| Synonyms name | IMR-90 ribosomal protein S3 40S ribosomal protein S3 |
| Locus | 11q13, 4 |
| Discovery year | 1994-12-02 |
| Entrez gene record | 6188 |
| Pubmed identfication | 1712897 7789996 |
| RefSeq identity | NM_001005 |
| Classification | S ribosomal proteins |
| Havana BLAST/BLAT | OTTHUMG00000165448 |
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