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RPTOR (1411CT316.2.151.34) Monoclonal Antibody

RPTOR (1411CT316.2.151.34) Monoclonal Antibody size: 0.1ml 211

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 211
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name2, 151, 34) Monoclonal Antibody, RPTOR (1411CT316
Also known as2, 151, 34) Monoclonal Antibody, RPTOR (1411CT316
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenRPTOR
SpecificityThis is a highly specific antibody against RPTOR
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityMonoclonal
Clone number1411CT316, 2, 34, 151
SourceThis RPTOR antibody is generated from a mouse immunized with recombinant protein
Gene ID number57521
Swiss ProtQ8N122
Tested Applications IHC-P, WB
Recommended dilutions WB(1:500-1:1000), IHC-P(1:25)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis, Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases, Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, Involved in ciliogenesis, and autophagy in response to nutrient and hormonal signals, functions as a scaffold for recruiting mTORC1 substrates, mTORC1 is activated in response to growth factors or amino acids, mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E), mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1, which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation, Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names KIAA1303, Mip1, RPTOR, Raptor, Regulatory-associated protein of mTOR, p150 target of rapamycin (TOR)-scaffold protein, KOG1
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
About Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones
Gene target2, 151, 34) Monoclonal, RPTOR (1411CT316
Short name2, 151, 34) Monoclonal Antibody, RPTOR (1411CT316
Technique Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody
Alternative name2, 151, 34) monoclonal (Antibody to), RPTOR (1411CT316
Alternative techniqueantibodies
Identity 30287
Gene RPTOR
Long gene name regulatory associated protein of MTOR complex 1
Synonyms gene name complex 1 , regulatory associated protein of MTOR
Synonyms KOG1 Mip1 KIAA1303 raptor
Synonyms name regulatory associated protein of mTOR
Locus 17q25, 3
Discovery year 2009-05-29
Entrez gene record 57521
Pubmed identfication 10718198 12150926
RefSeq identity NM_020761
Classification MTOR complex 1 WD repeat domain containing
Havana BLAST/BLAT OTTHUMG00000177622

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