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RSK2/3 (3C1) Monoclonal Antibody

RSK2/3 (3C1) Monoclonal Antibody size: 0.1ml 362

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 362
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameRSK2/3 (3C1) Monoclonal Antibody
Also known asRSK2/3 (3C1) Monoclonal Antibody
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenRSK2/3
SpecificityThis is a highly specific antibody against RSK2/3
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityMonoclonal
Clone number3C1
Concentration2ug/ul
Source), Recombinant human protein purified from E, a, coli(His/ABD-RSK3 415-733 a
Gene ID number6197
Swiss ProtP51812
Tested ApplicationsWB
Recommended dilutions0 ug/mL), WB (2
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Addition of growth factor to the cells results in the activation of both cytosolic and nuclear RSK and the translocation of the cytosolic RSK into the nucleus upon activation, ERK activates the C-terminal kinase of RSK, In humans, Members of the RSK family are present in the cytoplasm as well as the nucleus, NFkappaB/IkappaB &alpha, RSK family members are unusual among serine/threonine kinases in that they contain two distinct kinase domains, RSK regulates gene expression via association and phosphorylation of transcriptional regulators including c-Fos, The activation and nuclear translocation of RSK result in phosphorylation and activation of transcription factors, Theses kinase dimains are activated in a sequential manner by a series of phosphorylations, both of which are catalytically functional, cAMP-response element-binding protein (CREB), estrogen receptor, leading to activation of the N-terminal kinase, the RSK family consists of four isoforms (RSK1 to -4), The p90 ribosomal S6 kinases (RSKs) comprise a family of serine/threonine kinases that lie at the terminus of the ERK pathway
Purification methodPurified by Protein G
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names 90 kDa ribosomal protein S6 kinase 3, HU-3, ISPK-1, ISPK1, Insulin-stimulated protein kinase 1, MAP kinase-activated protein kinase 1b, MAPK-activated protein kinase 1b, MAPKAP kinase 1b, MAPKAPK-1b, MAPKAPK1B, MRX19, RPS6KA3, RSK, RSK-2, RSK2, Ribosomal S6 kinase 2, Ribosomal protein S6 kinase alpha-3, S6K-alpha-3, S6K-alpha3, p90-RSK 3, p90-RSK2, p90RSK3, pp90RSK2, CLS
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
About Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones
Gene targetRSK2/3 (3C1) Monoclonal
Short nameRSK2/3 (3C1) Monoclonal Antibody
Technique Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody
Alternative nameRSK2/3 (3C1) monoclonal (Antibody to)
Alternative techniqueantibodies
Identity 10432
Gene RPS6KA3
Long gene name ribosomal protein S6 kinase A3
Synonyms gene MRX19 CLS
Synonyms gene name 90kD, polypeptide 3 , ribosomal protein S6 kinase
Synonyms RSK RSK2 HU-3
Locus Xp22, 12
Discovery year 1994-07-11
GenBank acession U08316
Entrez gene record 6197
Pubmed identfication 8141249 11896450 16879200
RefSeq identity NM_004586
Classification X-linked mental retardation Mitogen-activated protein kinase-activated protein kinases
Havana BLAST/BLAT OTTHUMG00000021231
Locus Specific Databases Mental Retardation database

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