| Long name | RUNX1 + RUNX2 Primary Polyclonal Antibody |
| Also known as | RUNX1 + RUNX2 PAb |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | RUNX1+RUNX2 |
| Specificity | This is a highly specific antibody against RUNX1+RUNX2 |
| Modification(s) | None |
| Modification site(s) | Unmodified antibody |
| Clonality | Polyclonal antibody |
| Clone number | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Immunogen range | 200-250/521 |
| Source | This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human RUNX2 |
| Gene ID number | 860 |
| Swiss Prot | Q13950 |
| Tested Applications | IF(ICC), IF(IHC-P), IHC-P, WB |
| Recommended dilutions | IF(ICC)(1:50-200), IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity | Mouse, Rat, Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | 5'-PYGPYGGT-3', CBF binds to the core site, Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification, IL-3 and GM-CSF promoters, In osteoblasts, Inhibits KAT6B-dependent transcriptional activation, LCK, T-cell receptor enhancers, alpha 1(I) collagen, bone sialoprotein, including murine leukemia virus, of a number of enhancers and promoters, osteocalcin, osteopontin, polyomavirus enhancer, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity), Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis |
| Purification method | This antibody was purified via Protein A |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | AML3, Acute myeloid leukemia 3 protein, CBF-alpha-1, CBFA1, CCD1, CLCD, Core-binding factor subunit alpha-1, OSF-2, OSF2, Oncogene AML-3, Osteoblast-specific transcription factor 2, PEA2-alpha A, PEA2aA, PEBP2-alpha A, PEBP2A, PEBP2aA, Polyomavirus enhancer-binding protein 2 alpha A subunit, RUNX2, Runt-related transcription factor 2, SL3-3 enhancer factor 1 alpha A subunit, SL3/AKV core-binding factor alpha A subunit, CCD |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target | RUNX1 + RUNX2 |
| Short name | RUNX1 + RUNX2 Antibody |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Alternative name | runt-related transcription factor 1 and RUNX2 (Antibody to) |
| Alternative technique | antibodies |
| Alternative to gene target | AML1 and AML1-EVI-1 and AMLCR1 and CBFA2 and EVI-1 and PEBP2aB, DNA-templated and biological process this GO :0006355 and regulation of transcription, DNA-templated and biological process this GO :0007417 and central nervous system development and biological process this GO :0008134 and transcription factor binding and molecular function this GO :0009966 and regulation of signal transduction and biological process this GO :0030097 and hemopoiesis and biological process this GO :0030099 and myeloid cell differentiation and biological process this GO :0030182 and neuron differentiation and biological process this GO :0030853 and negative regulation of granulocyte differentiation and biological process this GO :0030854 and positive regulation of granulocyte differentiation and biological process this GO :0031069 and hair follicle morphogenesis and biological process this GO :0035162 and embryonic hemopoiesis and biological process this GO :0042803 and protein homodimerization activity and molecular function this GO :0045766 and positive regulation of angiogenesis and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046982 and protein heterodimerization activity and molecular function this GO :0048266 and behavioral response to pain and biological process this GO :0048666 and neuron development and biological process this GO :0048935 and peripheral nervous system neuron development and biological process this GO :0060216 and definitive hemopoiesis and biological process this GO :0070491 and repressing transcription factor binding and molecular function this GO :0071336 and regulation of hair follicle cell proliferation and biological process this GO :0071425 and hematopoietic stem cell proliferation and biological process this GO :0071560 and cellular response to transforming growth factor beta stimulus and biological process this GO :2000872 and positive regulation of progesterone secretion and biological process, RUNX1 and IDBG-2825 and ENSG00000159216 and 100506403, RUNX1 and IDBG-640443 and ENSBTAG00000004742 and 529631, Runx1 and IDBG-177713 and ENSMUSG00000022952 and 12394, nuclei, repressing transcription factor binding, this GO :0000975 and regulatory region DNA binding and molecular function this GO :0001501 and skeletal system development and biological process this GO :0001701 and in utero embryonic development and biological process this GO :0001889 and liver development and biological process this GO :0002318 and myeloid progenitor cell differentiation and biological process this GO :0003677 and DNA binding and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0005509 and calcium ion binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005604 and basement membrane and cellular component this GO :0005634 and nucleus and cellular component this GO :0006351 and transcription, this GO :0000975: regulatory region DNA binding, this GO :0000975: regulatory region DNA binding and also this GO :0003677: DNA binding and also this GO :0003700: sequence-specific DNA binding transcription factor activity and also this GO :0005509: calcium ion binding and also this GO :0005515: protein binding and also this GO :0005524: ATP binding and also this GO :0008134: transcription factor binding and also this GO :0042803: protein homodimerization activity and also this GO :0046982: protein heterodimerization activity and also this GO :0070491: repressing transcription factor binding, this GO :0003677: DNA binding, this GO :0003700: sequence-specific DNA binding transcription factor activity, this GO :0005509: calcium ion binding, this GO :0005515: protein binding, this GO :0005524: ATP binding, this GO :0008134: transcription factor binding, this GO :0042803: protein homodimerization activity, this GO :0046982: protein heterodimerization activity, this GO :0070491: repressing transcription factor binding, 861, 101928269, runt-related transcription factor 1 |
| Identity | 10472 |
| Gene | RUNX2 |
| Long gene name | runt related transcription factor 2 |
| Synonyms gene | CCD CBFA1 CCD1 |
| Synonyms gene name | runt-related transcription factor 2 |
| Synonyms | AML3 PEBP2A1 PEBP2aA1 |
| Locus | 6p21, 1 |
| Discovery year | 1994-11-02 |
| GenBank acession | AF001450 |
| Entrez gene record | 860 |
| Pubmed identfication | 7835892 |
| RefSeq identity | NM_004348 |
| Havana BLAST/BLAT | OTTHUMG00000014774 |
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