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RUVBL1 (507CT2.2.2) Monoclonal Antibody

RUVBL1 (507CT2.2.2) Monoclonal Antibody size: 0.1ml 211

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 211
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name2, 2) Monoclonal Antibody, RUVBL1 (507CT2
Also known as2, 2) Monoclonal Antibody, RUVBL1 (507CT2
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenRUVBL1
SpecificityThis is a highly specific antibody against RUVBL1
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityMonoclonal
Clone number2, 2, 507CT2
SourcePurified His-tagged RUVBL1 protein(Fragment) was used to produced this monoclonal antibody
Gene ID number8607
Swiss ProtQ9Y265
Tested ApplicationsWB
Recommended dilutionsWB(1:100~500)
Cross reactivityHuman
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Component of a SWR1-like complex that specifically mediates the removal of histone H2A, Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A, DNA replication and probably DNA repair, Essential for cell proliferation, May be able to bind plasminogen at cell surface and enhance plasminogen activation, NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage, Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex, Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, The NuA4 complex ATPase and helicase activities seem to be, This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription, and DNA repair, apoptosis, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400, hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity, tumor suppressor mediated growth arrest and replicative senescence, Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity, Z/H2AFZ from the nucleosome
Purification method This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS, 09% (W/V) sodium azide, Purified monoclonal antibody supplied in PBS with 0
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names 49 kDa TATA box-binding protein-interacting protein, 49 kDa TBP-interacting protein, 54 kDa erythrocyte cytosolic protein, ECP-54, ECP54, INO80 complex subunit H, INO80H, NMP 238, NMP238, Nuclear matrix protein 238, PONTIN, Pontin 52, Pontin52, RUVBL1, RuvB-like 1, TAP54-alpha, TIH1, TIP49, TIP49A, TIP60-associated protein 54-alpha, RVB1
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
About Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones
Gene target2, 2) Monoclonal, RUVBL1 (507CT2
Short name2, 2) Monoclonal Antibody, RUVBL1 (507CT2
Technique Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody
Alternative name2, 2) monoclonal (Antibody to), RUVBL1 (507CT2
Alternative techniqueantibodies
Identity 10474
Gene RUVBL1
Long gene name RuvB like AAA ATPase 1
Synonyms gene name RuvB (E coli homolog)-like 1 RuvB-like 1 (E, coli) RuvB-like AAA ATPase RuvB-like AAA ATPase 1
Synonyms TIP49 NMP238 RVB1 TIP49a Pontin52 ECP54 TIH1 Rvb1 INO80H
Synonyms name pontin INO80 complex subunit H
Locus 3q21, 3
Discovery year 1998-11-19
GenBank acession AF070735
Entrez gene record 8607
Pubmed identfication 9774387 9588198
Classification AAA ATPases INO80 complex DNA helicases SRCAP complex
Havana BLAST/BLAT OTTHUMG00000159658

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