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SDF1 Antibody

SDF1 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameSDF1 Primary Polyclonal Antibody
Also known asSDF1 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenSDF1
SpecificityThis is a highly specific antibody against SDF1
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range55-90/93
Subcellular locationSecreted
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human SDF-1/CXCL12
Gene ID number6387
Swiss ProtP48061
Tested Applications IF(IHC-P), IHC-P
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis, Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase, Also binds to atypical chemokine receptor ACKR3, Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites, CXCR4 and ACKR3, Has several critical functions during embryonic development, Induces down-regulation and internalization of ACKR3 expressed in various cells, Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1, Plays a protective role after myocardial infarction, SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity, SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase, Stimulates migration of monocytes and T-lymphocytes through its receptors, a ligand for beta-2 integrins, and decreases monocyte adherence to surfaces coated with ICAM-1, but not neutrophils, monocytes, myelopoiesis in bone marrow and heart ventricular septum formation, required for B-cell lymphopoiesis, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1, Chemoattractant active on T-lymphocytes
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names C-X-C motif chemokine 12, CXCL12, Intercrine reduced in hepatomas, PBSF, Pre-B cell growth-stimulating factor, SCYB12, SDF-1, SDF1, SDF1A, SDF1B, Stromal cell-derived factor 1, TLSF, TPAR1, hIRH, hSDF-1, IRH
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetSDF1
Short nameSDF1 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameSDF1 (Antibody to)
Alternative techniqueantibodies
Identity 10672
Gene CXCL12
Long gene name C-X-C motif chemokine ligand 12
Synonyms gene SDF1A SDF1B SDF1
Synonyms gene name stromal cell-derived factor 1 chemokine (C-X-C motif) ligand 12
Synonyms SCYB12 SDF-1a SDF-1b PBSF TLSF-a TLSF-b TPAR1
Locus 10q11, 21
Discovery year 1994-11-30
GenBank acession L36033
Entrez gene record 6387
Pubmed identfication 7490086
RefSeq identity NM_000609
Classification Endogenous ligands Chemokine ligands
Havana BLAST/BLAT OTTHUMG00000018054

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