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SDF1 Antibody, Cy5.5 Conjugated

SDF1 Antibody, Cy5.5 Conjugated size: 0.1ml 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 350
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Cy5, 5 Conjugated, SDF1 Polyclonal Antibody
CategoryConjugated Primary Antibodies
Conjugation Cy5, 5, 5, Cy5
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenSDF1
SpecificityThis is a highly specific antibody against SDF1
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range55-90/93
Subcellular locationSecreted
SourceKLH conjugated synthetic peptide derived from human SDF-1/CXCL12
Gene ID number6387
Swiss ProtP48061
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis, Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase, Also binds to atypical chemokine receptor ACKR3, Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites, CXCR4 and ACKR3, Has several critical functions during embryonic development, Induces down-regulation and internalization of ACKR3 expressed in various cells, Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1, Plays a protective role after myocardial infarction, SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity, SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase, Stimulates migration of monocytes and T-lymphocytes through its receptors, a ligand for beta-2 integrins, and decreases monocyte adherence to surfaces coated with ICAM-1, but not neutrophils, monocytes, myelopoiesis in bone marrow and heart ventricular septum formation, required for B-cell lymphopoiesis, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1, Chemoattractant active on T-lymphocytes
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission675nm/694nm
Synonyms SCYB12 SDF-1a SDF-1b PBSF TLSF-a TLSF-b TPAR1
Properties Cy5 antibodies are excited by the 650-nanometer wave of an argon laser and detected at a 670-nanometer captor, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
ConjugatedThese antibodies are excite for emission at 678nm and detected at a 694 , nm wavelengths
Gene targetSDF1 Conjugated
Short name Conjugated, SDF1 Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
Label5, Cy5
Alternative name cyanine 5, 5 coupled, SDF1 (Antibody to)
Alternative techniqueantibodies
Identity 10672
Gene CXCL12
Long gene name C-X-C motif chemokine ligand 12
Synonyms gene SDF1A SDF1B SDF1
Synonyms gene name stromal cell-derived factor 1 chemokine (C-X-C motif) ligand 12
Locus 10q11, 21
Discovery year 1994-11-30
GenBank acession L36033
Entrez gene record 6387
Pubmed identfication 7490086
RefSeq identity NM_000609
Classification Endogenous ligands Chemokine ligands
Havana BLAST/BLAT OTTHUMG00000018054

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