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Senataxin/SETX Antibody

Senataxin/SETX Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameSenataxin/SETX Primary Polyclonal Antibody
Also known asSenataxin/SETX PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenSenataxin/SETX
SpecificityThis is a highly specific antibody against Senataxin/SETX
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range345-395/2677
Subcellular location Nucleus, Cytoplasm
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Senataxin
Gene ID number23064
Swiss ProtQ7Z333
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Contributes to the mRNA splicing efficiency and splice site selection (PubMed:19515850), In association with RRP45, Inhibits retinoic acid-induced apoptosis (PubMed:21576111), Involved in DNA double-strand breaks damage response generated by oxidative stress (PubMed:17562789), May be involved in telomeric stability through the regulation of telomere repeat-containing RNA (TERRA) transcription (PubMed:21112256), Plays a role in neurite outgrowth in hippocampal cells through FGF8-activated signaling pathways, Plays a role in the development and maturation of germ cells: essential for male meiosis, Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription (PubMed:19515850, PubMed:21700224), PubMed:21700224), Required for the 3' transcriptional termination of PER1 and CRY2, Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, acting at the interface of transcription and meiotic recombination, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (PubMed:19515850, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI) (By similarity), targets the RNA exosome complex to sites of transcription-induced DNA damage (PubMed:24105744), thus playing an important role in the circadian rhythm regulation (By similarity), Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names AOA2, Amyotrophic lateral sclerosis 4 protein, KIAA0625, Probable helicase senataxin, SCAR1, SEN1 homolog, SETX, Senataxin, bA479K20, 2, ALS4
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetSenataxin/SETX
Short nameSenataxin/SETX Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameSenataxin/SETX (Antibody to)
Alternative techniqueantibodies
Identity 445
Gene SETX
Long gene name senataxin
Synonyms gene ALS4 SCAR1
Synonyms gene name amyotrophic lateral sclerosis 4 spinocerebellar ataxia, non-Friedreich type 1 , recessive
Synonyms KIAA0625 AOA2
Locus 9q34, 13
Discovery year 1996-10-26
GenBank acession AB014525
Entrez gene record 23064
Pubmed identfication 9497266 11022012
RefSeq identity NM_015046
Classification UPF1 like RNA helicases
Havana BLAST/BLAT OTTHUMG00000020834
Locus Specific Databases Inherited Peripheral Neuropathies Mutation Database LOVD - Leiden Open Variation Database ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database LRG_268

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