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Senataxin/SETX Antibody, Cy7 Conjugated

Senataxin/SETX Antibody, Cy7 Conjugated size: 0.1ml 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 350
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Cy7 Conjugated, Senataxin/SETX Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationCy7
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenSenataxin/SETX
SpecificityThis is a highly specific antibody against Senataxin/SETX
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range345-395/2677
Subcellular location Nucleus, Cytoplasm
SourceKLH conjugated synthetic peptide derived from human Senataxin
Gene ID number23064
Swiss ProtQ7Z333
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Contributes to the mRNA splicing efficiency and splice site selection (PubMed:19515850), In association with RRP45, Inhibits retinoic acid-induced apoptosis (PubMed:21576111), Involved in DNA double-strand breaks damage response generated by oxidative stress (PubMed:17562789), May be involved in telomeric stability through the regulation of telomere repeat-containing RNA (TERRA) transcription (PubMed:21112256), Plays a role in neurite outgrowth in hippocampal cells through FGF8-activated signaling pathways, Plays a role in the development and maturation of germ cells: essential for male meiosis, Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription (PubMed:19515850, PubMed:21700224), PubMed:21700224), Required for the 3' transcriptional termination of PER1 and CRY2, Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, acting at the interface of transcription and meiotic recombination, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (PubMed:19515850, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI) (By similarity), targets the RNA exosome complex to sites of transcription-induced DNA damage (PubMed:24105744), thus playing an important role in the circadian rhythm regulation (By similarity), Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission743nm/767nm
Synonyms KIAA0625 AOA2
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
ConjugatedThese antibodies are excite for emission at 650 nm and detected at a 676 nm wavelengths
Gene targetSenataxin/SETX Conjugated
Short name Conjugated, Senataxin/SETX Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelCy7
Alternative name cyanine 7 coupled, Senataxin/SETX (Antibody to)
Alternative techniqueantibodies
Identity 445
Gene SETX
Long gene name senataxin
Synonyms gene ALS4 SCAR1
Synonyms gene name amyotrophic lateral sclerosis 4 spinocerebellar ataxia, non-Friedreich type 1 , recessive
Locus 9q34, 13
Discovery year 1996-10-26
GenBank acession AB014525
Entrez gene record 23064
Pubmed identfication 9497266 11022012
RefSeq identity NM_015046
Classification UPF1 like RNA helicases
Havana BLAST/BLAT OTTHUMG00000020834
Locus Specific Databases Inherited Peripheral Neuropathies Mutation Database LOVD - Leiden Open Variation Database ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database LRG_268

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