| Long name | ALEXA FLUOR 488 Conjugated, SFRP1 Polyclonal Antibody |
| Also known as | Anti-SFRP1 PAb ALEXA FLUOR 488 |
| Category | Conjugated Primary Antibodies |
| Conjugated with | 488, ALEXA FLUOR® |
| Host Organism | Rabbit (Oryctolagus cuniculus) |
| Target Antigen | SFRP1 |
| Specificity | This is a highly specific antibody against SFRP1 |
| Modification | Unmodified |
| Modification Site | None |
| Clonality | Polyclonal |
| Clone | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Immunogen range | 265-310/314 |
| Subcellular location | Secreted |
| Source | This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human SFRP1 |
| Gene ID Number | 6422 |
| Swiss Prot | Q8N474 |
| Tested applications | IF(IHC-P) |
| Recommended dilutions | IF(IHC-P)(1:50-200) |
| Crossreactivity | Mouse, Rat, Human |
| Cross-reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen | Has antiproliferative effects on vascular cells, In kidney development, In vascular cell cycle, Inhibits WNT1/WNT4-mediated TCF-dependent transcription, SFRP1 decreases intracellular beta-catenin levels (By similarity), They have a role in regulating cell growth and differentiation in specific cell types, an angiogenic response, and can induce, delays the G1 phase and entry into the S phase (By similarity), in vitro and in vivo, in vivo, inhibits tubule formation and bud growth in metanephroi (By similarity), Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts |
| Purification | Purified by Protein A |
| Storage conditions | 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission | 499nm/519nm |
| Synonyms | SARP2 FRP FRP-1 |
| Properties | ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the SFRP1 Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation | Alexa Fluor |
| Gene target | SFRP1 |
| Short name | SFRP1 Antibody |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Label | ALEXA FLUOR 488 |
| Alternative name | ALEXA FLUOR 488, secreted frizzled-related protein 1 (Antibody to) |
| Alternative technique | antibodies |
| Alternative to gene target | BT, DNA-templated and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0046546 and development of primary male sexual characteristics and biological process this GO :0046676 and negative regulation of insulin secretion and biological process this GO :0046851 and negative regulation of bone remodeling and biological process this GO :0048147 and negative regulation of fibroblast proliferation and biological process this GO :0048546 and digestive tract morphogenesis and biological process this GO :0050679 and positive regulation of epithelial cell proliferation and biological process this GO :0050680 and negative regulation of epithelial cell proliferation and biological process this GO :0050732 and negative regulation of peptidyl-tyrosine phosphorylation and biological process this GO :0051496 and positive regulation of stress fiber assembly and biological process this GO :0051894 and positive regulation of focal adhesion assembly and biological process this GO :0060070 and canonical Wnt signaling pathway and biological process this GO :0060071 and Wnt signaling pathway, Extracellular, FRP and FRP-1 and FRP1 and FrzA and SARP2, SFRP1 and IDBG-18868 and ENSG00000104332 and 6422, Sfrp1 and IDBG-142213 and ENSMUSG00000031548 and 20377, Wnt-activated receptor activity, planar cell polarity pathway and biological process this GO :0060218 and hematopoietic stem cell differentiation and biological process this GO :0060346 and bone trabecula formation and biological process this GO :0060527 and prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis and biological process this GO :0060687 and regulation of branching involved in prostate gland morphogenesis and biological process this GO :0060766 and negative regulation of androgen receptor signaling pathway and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0071305 and cellular response to vitamin D and biological process this GO :0071347 and cellular response to interleukin-1 and biological process this GO :0071356 and cellular response to tumor necrosis factor and biological process this GO :0071363 and cellular response to growth factor stimulus and biological process this GO :0071380 and cellular response to prostaglandin E stimulus and biological process this GO :0071391 and cellular response to estrogen stimulus and biological process this GO :0071392 and cellular response to estradiol stimulus and biological process this GO :0071456 and cellular response to hypoxia and biological process this GO :0071481 and cellular response to X-ray and biological process this GO :0071504 and cellular response to heparin and biological process this GO :0071560 and cellular response to transforming growth factor beta stimulus and biological process this GO :0071773 and cellular response to BMP stimulus and biological process this GO :0090090 and negative regulation of canonical Wnt signaling pathway and biological process this GO :0090175 and regulation of establishment of planar polarity and biological process this GO :0090179 and planar cell polarity pathway involved in neural tube closure and biological process this GO :0090244 and Wnt signaling pathway involved in somitogenesis and biological process this GO :0090246 and convergent extension involved in somitogenesis and biological process this GO :0090263 and positive regulation of canonical Wnt signaling pathway and biological process this GO :1902043 and positive regulation of extrinsic apoptotic signaling pathway via death domain receptors and biological process this GO :2000041 and negative regulation of planar cell polarity pathway involved in axis elongation and biological process this GO :2000052 and positive regulation of non-canonical Wnt signaling pathway and biological process this GO :2000054 and negative regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification and biological process this GO :2000080 and negative regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation and biological process this GO :2000270 and negative regulation of fibroblast apoptotic process and biological process this GO :2000271 and positive regulation of fibroblast apoptotic process and biological process this GO :2001238 and positive regulation of extrinsic apoptotic signaling pathway and biological process, this GO :0001649 and osteoblast differentiation and biological process this GO :0001657 and ureteric bud development and biological process this GO :0001756 and somitogenesis and biological process this GO :0001843 and neural tube closure and biological process this GO :0001944 and vasculature development and biological process this GO :0001954 and positive regulation of cell-matrix adhesion and biological process this GO :0002244 and hematopoietic progenitor cell differentiation and biological process this GO :0004197 and cysteine-type endopeptidase activity and molecular function this GO :0005109 and frizzled binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005578 and proteinaceous extracellular matrix and cellular component this GO :0005615 and extracellular space and cellular component this GO :0005622 and intracellular and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006508 and proteolysis and biological process this GO :0007420 and brain development and biological process this GO :0008144 and drug binding and molecular function this GO :0008201 and heparin binding and molecular function this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0008406 and this GO nad development and biological process this GO :0008584 and male this GO nad development and biological process this GO :0008585 and female this GO nad development and biological process this GO :0009267 and cellular response to starvation and biological process this GO :0009950 and dorsal/ventral axis specification and biological process this GO :0009952 and anterior/posterior pattern specification and biological process this GO :0009986 and cell surface and cellular component this GO :0010564 and regulation of cell cycle process and biological process this GO :0010629 and negative regulation of gene expression and biological process this GO :0010719 and negative regulation of epithelial to mesenchymal transition and biological process this GO :0014034 and neural crest cell fate commitment and biological process this GO :0014070 and response to organic cyclic compound and biological process this GO :0017147 and Wnt-protein binding and molecular function this GO :0021915 and neural tube development and biological process this GO :0022601 and menstrual cycle phase and biological process this GO :0030097 and hemopoiesis and biological process this GO :0030165 and PDZ domain binding and molecular function this GO :0030177 and positive regulation of Wnt signaling pathway and biological process this GO :0030178 and negative regulation of Wnt signaling pathway and biological process this GO :0030279 and negative regulation of ossification and biological process this GO :0030307 and positive regulation of cell growth and biological process this GO :0030308 and negative regulation of cell growth and biological process this GO :0030336 and negative regulation of cell migration and biological process this GO :0030514 and negative regulation of BMP signaling pathway and biological process this GO :0031012 and extracellular matrix and cellular component this GO :0032855 and positive regulation of Rac GTPase activity and biological process this GO :0033689 and negative regulation of osteoblast proliferation and biological process this GO :0035019 and somatic stem cell maintenance and biological process this GO :0042493 and response to drug and biological process this GO :0042802 and identical protein binding and molecular function this GO :0042813 and Wnt-activated receptor activity and molecular function this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043508 and negative regulation of JUN kinase activity and biological process this GO :0044344 and cellular response to fibroblast growth factor stimulus and biological process this GO :0044345 and stromal-epithelial cell signaling involved in prostate gland development and biological process this GO :0045578 and negative regulation of B cell differentiation and biological process this GO :0045600 and positive regulation of fat cell differentiation and biological process this GO :0045668 and negative regulation of osteoblast differentiation and biological process this GO :0045671 and negative regulation of osteoclast differentiation and biological process this GO :0045765 and regulation of angiogenesis and biological process this GO :0045880 and positive regulation of smoothened signaling pathway and biological process this GO :0045892 and negative regulation of transcription, this GO :0004197: cysteine-type endopeptidase activity, this GO :0004197: cysteine-type endopeptidase activity and also this GO :0005109: frizzled binding and also this GO :0005515: protein binding and also this GO :0008144: drug binding and also this GO :0008201: heparin binding and also this GO :0017147: Wnt-protein binding and also this GO :0030165: PDZ domain binding and also this GO :0042802: identical protein binding and also this GO :0042813: Wnt-activated receptor activity, this GO :0005109: frizzled binding, this GO :0005515: protein binding, this GO :0008144: drug binding, this GO :0008201: heparin binding, this GO :0017147: Wnt-protein binding, this GO :0030165: PDZ domain binding, this GO :0042802: identical protein binding, this GO :0042813: Wnt-activated receptor activity, 85254 and IDBG-629640 and ENSBTAG00000027625 and 282068, secreted frizzled-related protein 1 |
| Identity | 10776 |
| Gene | SFRP1 |
| Long gene name | secreted frizzled related protein 1 |
| Locus | 8p11, 21 |
| Discovery year | 1998-07-15 |
| GenBank acession | AF017987 |
| Entrez gene record | 6422 |
| Pubmed identfication | 9391078 9192640 |
| RefSeq identity | NM_003012 |
| Classification | Secreted frizzled-related proteins |
| Havana BLAST/BLAT | OTTHUMG00000164074 |
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