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SH2D1A Antibody

SH2D1A Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameSH2D1A Primary Polyclonal Antibody
Also known asSH2D1A PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenSH2D1A
SpecificityThis is a highly specific antibody against SH2D1A
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human SH2D1A/SAP
Gene ID number4068
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen 128 amino acid protein that is 96% homologous to the mouse protein in both SH2 and tail domains, CD229 (LY9) and CD244 (2B4), CD45RA+ and CD8+, CD45RO+, CD84, SAP and CD150/SLAM (signaling lymphocyte activation molecule)-associated protein, SH2D1A can interact via an SH2 domain with a motif (TIYXXV) present in the cytoplasmic tail of cell-surface receptors SLAM (CD150), SH2D1A is a hydrophilic, SH2D1A is present in all major subsets of T cells, SH2D1A modulates SLAM by blocking the recruitment of tyrosine phosphatase SHP2 to the phosphorylated cytoplasmic domain of SLAM, SLAM activation mediates expansion of activated T cells during immune responses, also SH2 domain protein 1A, but not in B cells, including CD4+, induces production of interferon-?and changes the functional profile of subsets of T cells, influences signaling pathways involving SLAM molecules at the interface between T and B cells, SH2D1A
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names DSHP, Duncan disease SH2 protein, SAP, SH21A_HUMAN, SLAM associated protein, Signaling lymphocyte activation molecule associated protein, T cell signal transduction molecule SAP, SH2 domain protein 1A
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetSH2D1A
Short nameSH2D1A Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameSH2 domain containing 1A (Antibody to)
Alternative techniqueantibodies
Alternative to gene target Cytoplasm, DSHP and EBVS and IMD5 and LYP and MTCP1 and SAP and SAP/SH2D1A and XLP and XLPD and XLPD1, SH2D1A and IDBG-630222 and ENSBTAG00000026067 and 613356, SH2D1A and IDBG-85368 and ENSG00000183918 and 4068, Sh2d1a and IDBG-141610 and ENSMUSG00000005696 and 20400, protein binding, this GO :0005070 and SH3/SH2 adaptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0006959 and humoral immune response and biological process this GO :0006968 and cellular defense response and biological process this GO :0007267 and cell-cell signaling and biological process this GO :0009967 and positive regulation of signal transduction and biological process this GO :0045087 and innate immune response and biological process this GO :0045954 and positive regulation of natural killer cell mediated cytotoxicity and biological process, this GO :0005070: SH3/SH2 adaptor activity, this GO :0005070: SH3/SH2 adaptor activity and also this GO :0005515: protein binding, this GO :0005515: protein binding, SH2 domain containing 1A
Identity 10820
Gene SH2D1A
Long gene name SH2 domain containing 1A
Synonyms gene IMD5 LYP
Synonyms gene name lymphoproliferative syndrome SH2 domain protein 1A
Synonyms XLP MTCP1 DSHP XLPD EBVS SAP
Synonyms name Duncan', s disease
Locus Xq25
Discovery year 1989-06-30
GenBank acession AL023657
Entrez gene record 4068
Pubmed identfication 9771704 9774102
RefSeq identity NM_002351
Classification SH2 domain containing
Havana BLAST/BLAT OTTHUMG00000022344
Locus Specific Databases SH2D1Abase: Mutation registry for X-linked lymphoproliferative syndrome (XLP) LRG_106

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