Name : SHANK3 Antibody, ALEXA FLUOR 555
Supplier : BIOSS PRIMARY CONJUGATED ANTIBODIES
Price :332
SKU : GEN4405044474
| Long name | ALEXA FLUOR 555 Conjugated, SHANK3 Polyclonal Antibody |
| Also known as | Anti-SHANK3 PAb ALEXA FLUOR 555 |
| Category | Conjugated Primary Antibodies |
| Conjugated with | 555, ALEXA FLUOR® |
| Host Organism | Rabbit (Oryctolagus cuniculus) |
| Target Antigen | SHANK3 |
| Specificity | This is a highly specific antibody against SHANK3 |
| Modification | Unmodified |
| Modification Site | None |
| Clonality | Polyclonal |
| Clone | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Immunogen range | 1165-1215/1741 |
| Subcellular location | Cytoplasm |
| Source | This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human SHANK3 |
| Gene ID Number | 85358 |
| Swiss Prot | Q9BYB0 |
| Tested applications | IF(IHC-P) |
| Recommended dilutions | IF(IHC-P)(1:50-200) |
| Crossreactivity | Mouse, Rat, Human |
| Cross-reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen | Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity, By way of this control of actin dynamics, Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation, Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters, and the actin-based cytoskeleton, maturation and maintenance, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling, respectively, Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation |
| Purification | Purified by Protein A |
| Storage conditions | 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission | 553nm/568nm |
| Synonyms | SPANK-2 prosap2 KIAA1650 PSAP2 |
| Properties | ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, Very high photo stable ALEXA conjugate, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation | ALEXA FLUOR 555, Alexa Fluor |
| Gene target | SHANK3 |
| Short name | SHANK3 Antibody |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Label | ALEXA FLUOR 555 |
| Alternative name | ALEXA FLUOR 555, SHANK3 (Antibody to) |
| Alternative technique | antibodies |
| Identity | 14294 |
| Gene | SHANK3 |
| Long gene name | SH3 and multiple ankyrin repeat domains 3 |
| Synonyms name | proline rich synapse associated protein 2 shank postsynaptic density protein |
| Locus | 22q13, 33 |
| Discovery year | 2002-02-22 |
| GenBank acession | AB051437 |
| Entrez gene record | 85358 |
| Pubmed identfication | 11258795 11431708 10806096 17173049 |
| RefSeq identity | NM_001080420 |
| Classification | Ankyrin repeat domain containing Sterile alpha motif domain containing PDZ domain containing |
| Havana BLAST/BLAT | OTTHUMG00000150169 |