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SHC2/Sck Antibody

SHC2/Sck Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameSHC2/Sck Primary Polyclonal Antibody
Also known asSHC2/Sck PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenSHC2/Sck
SpecificityThis is a highly specific antibody against SHC2/Sck
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human SHC2/Sck
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Human Sck transcripts are present at high levels in liver, In vascular endothelial cells, Sck participates in VEGF-induced signal transduction (6), Shc-like protein (Sck) is a neuronal adaptor protein that contains an N-terminal PTB (phosphotyrosine binding) domain, Treatment of human umbilical vein endothelial (HUVEC) cells with VEGF induces recruitment of Sck to tyrosine-1175 of the kinase insert domain-containing receptor (KDR) and enhances Sck tyrosine phosphorylation (7, a collagen homology (CH) domain, and a conserved C-terminal SH2 domain (2, pancreas, prostate and ovary (4, 3), 5), 8), Src homology 2 (SH2) domains bind specifically to tyrosine-phosphorylated proteins that temporally participate in signal transduction events (1)
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names SCK, SH2 domain protein C2, SHC transforming protein 2, SHC2_HUMAN, SHCB, Src homology 2 domain containing transforming protein C2, Protein Sck
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetSHC2/Sck
Short nameSHC2/Sck Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameSHC2/Sck (Antibody to)
Alternative techniqueantibodies
Identity 29869
Gene SHC2
Long gene name SHC adaptor protein 2
Synonyms gene name SHC (Src homology 2 domain containing) transforming protein 2
Synonyms SLI SCK SHCB
Synonyms name neuronal Shc adaptor homolog
Locus 19p13, 3
Discovery year 2004-03-18
GenBank acession AB001451
Entrez gene record 25759
Pubmed identfication 7527937 9507002
Classification SH2 domain containing
Havana BLAST/BLAT OTTHUMG00000180545

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