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SHEEP ANTI HUMAN LOX-1 Antibody

SHEEP ANTI HUMAN LOX-1 Antibody size: 50ug 531

Supplier MBS POLYCLONALS 1
Price 531
Size 50ug
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Alternative name1Anti-SHEEP ANTI HUMAN LOX-1
Alternative name2Ovine ANTI HUMAN LOX-1
Alternative name3Ovinae ANTI Homo sapiens LOX-1
Alternative name4LOX-1
Alternative name5N/A
Other names C-type lectin domain family 8 member A, C-type lectin domain family 8 member A, LOX-1, Lectin-like oxLDL receptor 1, Lectin-like oxidized LDL receptor 1, Lectin-type oxidized LDL receptor 1, Oxidized low-density lipoprotein receptor 1, hLOX-1, hLOX-1, lectin-type oxidized LDL receptor 1, member 1, ox LDL receptor 1, oxidized low density lipoprotein (lectin-like) receptor 1, oxidized low-density lipoprotein receptor 1, oxidized low-density lipoprotein receptor 1, scavenger receptor class E, soluble form, oxidized low-density lipoprotein receptor 1 isoform 2
Gene nameLOX-1
Gene name synonimsN/A
Other gene names CLEC8A, CLEC8A, LOX-1, LOX1, LOX1, LOXIN, Lectin-like oxLDL receptor 1, OLR1, Ox-LDL receptor 1, SCARE1, SLOX1, hLOX-1, OLR1
CategoryAntibodies
ClonalityPolyclonal
Immunoglobulin isotypePolyclonal IgG
ClonePolyclonal antibody
Host organismSheep
Species reactivityHuman
Specificity and cross-reactivity Angiotensin II and the inflammatory cytokine Tumour Necrosis Factor alpha (TNFalpha) also invoke an increase in LOX-1 gene expression and studies have focused on its role in endothelial dysfunction and inflammatory diseases such as atherosclerosis and rheumatoid arthritis, Expression of the LOX-1 gene is upregulated by oxLDL and the binding of LOX-1 to oxLDL results in the activation of NF-kappaB, Furthermore, LOX-1 antibodies have been shown to suppress the oxidized HDL (oxHDL) activation of NF-KappaB in endothelial cells, LOX-1 binds to a wide range of ligands, LOX-1 levels are low in normal resting human tissues so may fall below detectable levels, This item will detect LOX-1 on transfected cells and in recombinant protein reconstitution assays, a 40-50kDa class E scavenger receptor, activated platelets and bacteria, activated platelets and smooth muscle cells, aged/apoptotic cells, as well as its affect on CD40/CD40L signaling in both atherosclerosis and human coronary artery endothelial cells (HCAECs), expressed by endothelial cells, hypochlorite modified high-density lipoprotein (HDL), including oxidized low-density lipoprotein (oxLDL), macrophages, reflecting its versatile physiological functions, suggesting that this activation may be due to the binding of oxHDL to LOX-1, LOX-1 This item recognizes the type II membrane glycoprotein LOX-1 (lectin-like oxidized LDL receptor-1)
Purification methodN/A
Form/AppearancePurified (Purified IgG - liquid)
Concentration1 miligram per 1 mililiter, IgG concentration 0
Storage and shipping Avoid repeated freezing and thawing as this may denature the antibody, Shelf Life: 18 months from date of dispatch, Should productone contain a precipitate we recommend microcentrifugation before use, Storage in frost-free freezers is not recommended, if preferred, or productone should be stored at -20 degrees Celsius, productone should be stored undiluted, Store at +Store productone at +4 degrees Celsius
Tested for: Flow Cytometry (FACS), Immunohistology - Frozen (IHC), Immunoprecipitation (IP), Western Blot (WB)
Description Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions, Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, Properly used, To obtain more detailed information on productone, please, refer to the full product datasheet, the time needed for production is considerably shorter, they are inexpensive to manufacture and respectively to buy, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in, productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, avoid cycles of freezing and thawing, please, In order to retain the quality and the affinity of productone unchanged
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS Polyclonals_1 they should be stored frozen at - 24°
Gene targetLOX-1
Short nameSHEEP ANTI HUMAN LOX-1 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative name sapiens LOX-1 (Antibody to), ovine antibody to H
Alternative techniqueantibodies
Identity 8133
Gene OLR1
Long gene name oxidized low density lipoprotein receptor 1
Synonyms gene name oxidised low density lipoprotein (lectin-like) receptor 1
Synonyms LOX-1 SCARE1 CLEC8A
Locus 12p13, 2
Discovery year 1998-01-16
GenBank acession D89050
Entrez gene record 4973
Pubmed identfication 9763655
RefSeq identity NM_002543
Classification Scavenger receptors C-type lectin domain family
Havana BLAST/BLAT OTTHUMG00000168527

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