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SIGLEC7 Antibody (D-siglec)

SIGLEC7 Antibody (D-siglec) size: 0.08 ml 199

Supplier NJS POLY
Price 199
Size 0.08 ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration09% sodium azide, 4 with 0, In 1X PBS pH 7
FormAntigen affinity purified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenSIGLEC7 (D-siglec)
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications ELISA, IHC, WB
Recommended dilutionsIHC (Paraffin): 1:50-1:100, Western blot: 1:1000
NotesTitration of the SIGLEC7 antibody may be required due to differences in protocols and secondary/substrate sensitivity
Intented useThis SIGLEC7 antibodyis to be used only for research purposes and not for diagnostics
Uniprot #Q9Y286
PurityAntigen affinity
Description A large subgroup of SIGLECs share high homology with SIGLEC3 (CD33) and are localized to 19q13, Both variants contain 2 C2-set N-terminal Ig-like domains, Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, RT-PCR analysis detected high expression of both variants in spleen and small intestine, SLG-long (SLGL) and SLG-short (SLGS), The 477-amino acid SLGS protein has a weak signal sequence and, The 595-amino acid SLGL protein contains a signal peptide and 2 V-set N-terminal Ig-like domains, The cDNA for the SLG gene encodes 2 variants, The conserved arginine residue thought to be essential for sialic acid binding in other SIGLECs is replaced by a glutamine in SLGS and by a cysteine in SLGL, a transmembrane domain, and SLGS was highly expressed in adrenal gland and SLGL was highly expressed in bone marrow, and a cytoplasmic tail with a putative ITIM and a putative SLAM-like tyrosine-based motif, has only 1 V-set N-terminal Ig-like domain, like most SIGLEC3-like SIGLECs, or ITIMs, 4, SIGLECs are cell surface proteins of the Ig superfamily
ImmunogenA portion of amino acids 1-30 from the human protein was used as the immunogen for this SIGLEC7 antibody
Storage Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the SIGLEC7 antibody and store frozen at -20 deg
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetSIGLEC7 (D-siglec)
Short nameSIGLEC7 Antibody (D-siglec)
Technique antibodies against human proteins, antibodies for, Antibody
Alternative namesialic acid binding Ig-like lectin 7 (Antibody to) (D-siglec)
Alternative techniqueantibodies
Alternative to gene target Plasma membranes, SIGLEC7 and IDBG-65680 and ENSG00000168995 and 27036, carbohydrate binding, this GO :0004872 and receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005887 and integral component of plasma membrane and cellular component this GO :0007155 and cell adhesion and biological process this GO :0030246 and carbohydrate binding and molecular function this GO :0045087 and innate immune response and biological process, this GO :0004872: receptor activity, this GO :0004872: receptor activity and also this GO :0005515: protein binding and also this GO :0030246: carbohydrate binding, this GO :0005515: protein binding, this GO :0030246: carbohydrate binding, sialic acid binding Ig-like lectin 7
Identity 10876
Gene SIGLEC7
Long gene name sialic acid binding Ig like lectin 7
Synonyms gene SIGLEC19P SIGLECP2
Synonyms gene name pseudogene 2 sialic acid binding Ig-like lectin 7 , pseudogene sialic acid binding Ig-like lectin, sialic acid binding Ig-like lectin 19
Synonyms SIGLEC-7 p75/AIRM1 QA79 CD328
Locus 19q13, 41
Discovery year 2000-01-26
GenBank acession AF170485
Entrez gene record 27036
Pubmed identfication 10567377
RefSeq identity NM_016543
Classification CD molecules Sialic acid binding Ig like lectins V-set domain containing
Havana BLAST/BLAT OTTHUMG00000182895

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