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SIP1 Antibody (ZEB2)

SIP1 Antibody (ZEB2) size: 0.1mg 389

Supplier NJS POLY
Price 389
Size 0.1mg
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration2ml sterile DI water, 5mg/ml if reconstituted with 0
FormAntigen affinity purified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenSIP1 (ZEB2)
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applicationsWB
Recommended dilutions5-1ug/ml, Western blot: 0
Notes Titration of the SIP1 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts
Intented useThis ZEB2 antibodyis to be used only for research purposes and not for diagnostics
Uniprot #O60315
PurityAntigen affinity
Description Beltran et al, By radiation hybrid analysis, Expression of<, Nagase et al, The gene is a member of the ZEB1/Drosophila Zfh1 family of 2-handed zinc finger/homeodomain proteins and functions as a DNA-binding transcriptional repressor that interacts with activated<, Vandewalle et al, Wakamatsu et al, also known as Smad Interacting Protein 1 (SIP1) or Zinc finger homeobox 1B (ZFHX1B), and interacts with the nucleosome remodeling and histone deacetylation(NURD) complex, is a protein that in humans is encoded by the ZEB2 gene, the transducers of<, (1998) mapped the gene to chromosome 2, (2001) mapped the gene to chromosome 2q22, (2005) showed that expression of mouse Sip1 in human epithelial cells caused a morphologic change from an epithelial to a mesenchymal phenotype, (2008) showed that synthesis of SIP1 was upregulated following SNAI1 expression in human cell lines, /a>, /a>, /a>, /search_result, /search_result, /search_result, SMADs<, SNAI1<, TGF-beta<, Zinc finger E-box-binding homeobox 2, a href=, a href=, a href=, in epithelial cells triggers an epithelial-mesenchyme transition, php?search_txt=smad>, php?search_txt=snai1>, php?search_txt=tgf beta>, signaling
Immunogen mouse and rat), An amino acid sequence from the C-terminus of human Smad Interacting Protein 1 (DMQQRRKYQRKQGFQ) was used as the immunogen for this SIP1 antibody (100% homologous in human
Storage Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the SIP1 antibody can be stored for up to one month at 4oC, After reconstitution
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetSIP1 (ZEB2)
Short nameSIP1 Antibody (ZEB2)
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameSIP1 (Antibody to) (zinc finger E-box binding homeobox 2)
Alternative techniqueantibodies
Alternative to gene target BT, DNA-templated and biological process this GO :0006355 and regulation of transcription, DNA-templated and biological process this GO :0007399 and nervous system development and biological process this GO :0007417 and central nervous system development and biological process this GO :0019208 and phosphatase regulator activity and molecular function this GO :0021766 and hippocampus development and biological process this GO :0021846 and cell proliferation in forebrain and biological process this GO :0030177 and positive regulation of Wnt signaling pathway and biological process this GO :0043507 and positive regulation of JUN kinase activity and biological process this GO :0043565 and sequence-specific DNA binding and molecular function this GO :0045636 and positive regulation of melanocyte differentiation and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046872 and metal ion binding and molecular function this GO :0048023 and positive regulation of melanin biosynthetic process and biological process this GO :0048066 and developmental pigmentation and biological process this GO :0048598 and embryonic morphogenesis and biological process this GO :0070412 and R-SMAD binding and molecular function this GO :0097324 and melanocyte migration and biological process this GO :1903056 and regulation of melanosome organization and biological process, HSPC082 and SIP-1 and SIP1 and SMADIP1 and ZFHX1B, R-SMAD binding, ZEB2 and IDBG-71713 and ENSG00000169554 and 9839, Zeb2 and IDBG-168224 and ENSMUSG00000026872 and 24136, nuclei, this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0001755 and neural crest cell migration and biological process this GO :0001756 and somitogenesis and biological process this GO :0001843 and neural tube closure and biological process this GO :0003676 and nucleic acid binding and molecular function this GO :0003677 and DNA binding and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0005634 and nucleus and cellular component this GO :0006351 and transcription, this GO :0003676: nucleic acid binding, this GO :0003676: nucleic acid binding and also this GO :0003677: DNA binding and also this GO :0003700: sequence-specific DNA binding transcription factor activity and also this GO :0019208: phosphatase regulator activity and also this GO :0043565: sequence-specific DNA binding and also this GO :0046872: metal ion binding and also this GO :0070412: R-SMAD binding, this GO :0003677: DNA binding, this GO :0003700: sequence-specific DNA binding transcription factor activity, this GO :0019208: phosphatase regulator activity, this GO :0043565: sequence-specific DNA binding, this GO :0046872: metal ion binding, this GO :0070412: R-SMAD binding, 99328 and IDBG-642115 and ENSBTAG00000012615 and, zinc finger E-box binding homeobox 2
Identity 14881
Gene ZEB2
Long gene name zinc finger E-box binding homeobox 2
Synonyms gene ZFHX1B
Synonyms gene name zinc finger homeobox 1b
Synonyms KIAA0569 SIP-1 SIP1
Synonyms name SMAD interacting protein 1
Locus 2q22, 3
Discovery year 2001-03-14
GenBank acession AB011141
Entrez gene record 9839
RefSeq identity NM_014795
Classification ZF class homeoboxes and pseudogenes Zinc fingers C2H2-type
Havana BLAST/BLAT OTTHUMG00000187624

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