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SIRT4 Antibody, ALEXA FLUOR 647

SIRT4 Antibody, ALEXA FLUOR 647 size: 100ul 332

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES
Price 332
Size 100ul
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name ALEXA FLUOR 647 Conjugated, SIRT4 Polyclonal Antibody
Also known asAnti-SIRT4 PAb ALEXA FLUOR 647
CategoryConjugated Primary Antibodies
Conjugated with 647, ALEXA FLUOR®
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenSIRT4
SpecificityThis is a highly specific antibody against SIRT4
ModificationUnmodified
Modification SiteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen range60-110/314
Subcellular locationMitochondrion
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human SIRT4/SIR 2 like protein 4
Gene ID Number23409
Swiss ProtQ9Y6E7
Tested applications IF(IHC-F), IF(IHC-P)
Recommended dilutions IF(IHC-F)(1:50-200), IF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Cross-reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, Acts as a tumor suppressor, Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, Catalyzes the transfer of ADP-ribosyl groups onto target proteins, Down-regulates insulin secretion, In response to mTORC1 signal, SIRT4 expression is repressed, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity, inhibiting its activity, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest, promoting anaplerosis and cell proliferation, thereby acting as a regulator of lipid homeostasis, Acts both as NAD-dependent protein ADP-ribosyl transferase and NAD-dependent protein deacetylase
PurificationPurified by Protein A
Storage conditions 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission650nm/665nm
Synonyms SIR2L4
Properties ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode, ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 633 is a practical alternative to APC as well as Cy5, Bioss Primary Conjugated Antibodies, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is detected in the FL4 detector of the core's upgraded 2-laser FACScans, Like other Alexa Fluor dyes, exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy, the SIRT4 Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation ALEXA FLUOR 647, Alexa Fluor
Gene targetSIRT4
Short nameSIRT4 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
LabelALEXA FLUOR 647
Alternative name ALEXA FLUOR 647, SIRT4 (Antibody to)
Alternative techniqueantibodies
Identity 14932
Gene SIRT4
Long gene name sirtuin 4
Synonyms gene name S, cerevisiae, cerevisiae) , homolog) 4 sirtuin (silent mating type information regulation 2 homolog) 4 (S, sirtuin (silent mating type information regulation 2
Locus 12q24, 31
Discovery year 2001-03-20
GenBank acession AF083109
Entrez gene record 23409
Pubmed identfication 10381378
RefSeq identity NM_012240
Classification Sirtuins
Havana BLAST/BLAT OTTHUMG00000169028

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