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SIRT4 Antibody, Cy3 Conjugated

SIRT4 Antibody, Cy3 Conjugated size: 0.1ml 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 350
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Cy3 Conjugated, SIRT4 Polyclonal Antibody
CategoryConjugated Primary Antibodies
Conjugationcy3 conjugation kit
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenSIRT4
SpecificityThis is a highly specific antibody against SIRT4
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range60-110/314
Subcellular locationMitochondrion
SourceKLH conjugated synthetic peptide derived from human SIRT4/SIR 2 like protein 4
Gene ID number23409
Swiss ProtQ9Y6E7
Tested applications IF(IHC-F), IF(IHC-P)
Recommended dilutions IF(IHC-F)(1:50-200), IF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, Acts as a tumor suppressor, Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, Catalyzes the transfer of ADP-ribosyl groups onto target proteins, Down-regulates insulin secretion, In response to mTORC1 signal, SIRT4 expression is repressed, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity, inhibiting its activity, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest, promoting anaplerosis and cell proliferation, thereby acting as a regulator of lipid homeostasis, Acts both as NAD-dependent protein ADP-ribosyl transferase and NAD-dependent protein deacetylase
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission512, 550nm/570, 615nm
Synonyms SIR2L4
Properties 1 of the SIRT4 Antibody, Conjugated can be used in flow cytometry but typically shows lower fluorescence intensity comparable to that of PE or APC, Cy3 antibodies are excited by the 488-nanometer wave of an argon laser and the 633-nanometer line of a helium-neon diode laser, This Bioss Primary Conjugated Antibodies antibody is well suited for fluorescent microscopy, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetSIRT4 Conjugated
Short name Conjugated, SIRT4 Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelCy3
Alternative name cyanine 3 coupled, SIRT4 (Antibody to)
Alternative techniqueantibodies
Identity 14932
Gene SIRT4
Long gene name sirtuin 4
Synonyms gene name S, cerevisiae, cerevisiae) , homolog) 4 sirtuin (silent mating type information regulation 2 homolog) 4 (S, sirtuin (silent mating type information regulation 2
Locus 12q24, 31
Discovery year 2001-03-20
GenBank acession AF083109
Entrez gene record 23409
Pubmed identfication 10381378
RefSeq identity NM_012240
Classification Sirtuins
Havana BLAST/BLAT OTTHUMG00000169028

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