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SIRT4 Antibody, FITC Conjugated

SIRT4 Antibody, FITC Conjugated size: 0.1ml 333

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 333
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name FITC Conjugated, SIRT4 Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationAnti-FITC Antibody
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenSIRT4
SpecificityThis is a highly specific antibody against SIRT4
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range60-110/314
Subcellular locationMitochondrion
SourceKLH conjugated synthetic peptide derived from human SIRT4/SIR 2 like protein 4
Gene ID number23409
Swiss ProtQ9Y6E7
Tested applications IF(IHC-F), IF(IHC-P)
Recommended dilutions IF(IHC-F)(1:50-200), IF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, Acts as a tumor suppressor, Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, Catalyzes the transfer of ADP-ribosyl groups onto target proteins, Down-regulates insulin secretion, In response to mTORC1 signal, SIRT4 expression is repressed, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity, inhibiting its activity, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest, promoting anaplerosis and cell proliferation, thereby acting as a regulator of lipid homeostasis, Acts both as NAD-dependent protein ADP-ribosyl transferase and NAD-dependent protein deacetylase
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission494nm/518nm
Synonyms SIR2L4
Properties Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetSIRT4 Conjugated
Short name FITC Conjugated, SIRT4 Antibody
Technique Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelFITC
Alternative name fluorecein coupled, SIRT4 (Antibody to)
Alternative techniqueantibodies
Identity 14932
Gene SIRT4
Long gene name sirtuin 4
Synonyms gene name S, cerevisiae, cerevisiae) , homolog) 4 sirtuin (silent mating type information regulation 2 homolog) 4 (S, sirtuin (silent mating type information regulation 2
Locus 12q24, 31
Discovery year 2001-03-20
GenBank acession AF083109
Entrez gene record 23409
Pubmed identfication 10381378
RefSeq identity NM_012240
Classification Sirtuins
Havana BLAST/BLAT OTTHUMG00000169028

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