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SIRT6(Ser338) Antibody

SIRT6(Ser338) Antibody size: 0.1ml 281

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 281
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameSIRT6(Ser338) Primary Polyclonal Antibody
Also known asSIRT6(Ser338) PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenSIRT6 Ser338
SpecificityThis is a highly specific antibody against SIRT6 Ser338
Modification(s)Phosphorylation
Modification site(s)Ser338
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceKLH conjugated synthetic phosphopeptide derived from human SIRT6 around the phosphorylation site of Ser338
Gene ID number51548
Swiss ProtQ8N6T7
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivityHuman
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis, Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes, Deacetylation of nucleosomes interferes with RELA binding to target DNA, Has a role in the regulation of life span (By similarity), Has deacetylase activity towards histone H3K9Ac and H3K56Ac, Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate, May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance, Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle, Modulates cellular senescence and apoptosis, On DNA damage, Regulates the production of TNF protein, Required for genomic stability, Required for genomic stability, Required for normal IGF1 serum levels and normal glucose homeostasis, promotes DNA end resection via deacetylation of RBBP8, NAD-dependent protein deacetylase
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names NAD-dependent protein deacetylase sirtuin-6, Regulatory protein SIR2 homolog 6, SIR2-like protein 6, SIRT6, SIR2L6
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetSIRT6(Ser338)
Short nameSIRT6(Ser338) Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameSIRT6(Ser338) (Antibody to)
Alternative techniqueantibodies
Identity 14934
Gene SIRT6
Long gene name sirtuin 6
Synonyms gene name S, cerevisiae, cerevisiae) , homolog) 6 sirtuin (silent mating type information regulation 2 homolog) 6 (S, sirtuin (silent mating type information regulation 2
Locus 19p13, 3
Discovery year 2001-03-20
GenBank acession AF233396
Entrez gene record 51548
Pubmed identfication 10873683
Classification Sirtuins
Havana BLAST/BLAT OTTHUMG00000181847

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