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SIRT7 Antibody

SIRT7 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameSIRT7 Primary Polyclonal Antibody
Also known asSIRT7 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenSIRT7
SpecificityThis is a highly specific antibody against SIRT7
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range250-300/400
Subcellular location Nucleus, Cytoplasm
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human SIRT7
Gene ID number51547
Swiss ProtQ9NRC8
Tested Applications IF(IHC-F), IF(IHC-P), IHC-F, IHC-P, WB
Recommended dilutions IF(IHC-F)(1:50-200), IF(IHC-P)(1:50-200), IHC-F(1:100-500), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Also required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis: promotes the association of RNA polymerase I with the rDNA promoter region and coding region, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells, H3K18Ac, H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors, In contrast to other histone deacetylases, May also deacetylate p53/TP53 and promotes cell survival, Moreover, SIRT7 thereby acts as a transcription repressor, Stimulates transcription activity of the RNA polymerase I complex, These data suggest that SIRT7 may play a key role in oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac at promoter regions, directly linked to control of gene expression, displays selectivity for a single histone mark, however such data need additional confirmation, NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac)
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names NAD-dependent protein deacetylase sirtuin-7, Regulatory protein SIR2 homolog 7, SIR2-like protein 7, SIRT7, SIR2L7
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetSIRT7
Short nameSIRT7 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameSIRT7 (Antibody to)
Alternative techniqueantibodies
Identity 14935
Gene SIRT7
Long gene name sirtuin 7
Synonyms gene name S, cerevisiae) , homolog) 7 sirtuin (silent mating type information regulation 2 homolog) 7 (S, sirtuin (silent mating type information regulation 2, cerevisiae
Locus 17q25, 3
Discovery year 2001-03-20
GenBank acession AF233395
Entrez gene record 51547
Pubmed identfication 10873683 16618798
RefSeq identity NM_016538
Classification Sirtuins
Havana BLAST/BLAT OTTHUMG00000177957

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