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SLP76 Antibody

SLP76 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameSLP76 Primary Polyclonal Antibody
Also known asSLP76 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenSLP76
SpecificityThis is a highly specific antibody against SLP76
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human SLP76
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Although SLP-76 does not contain a motif that would indicate it to be a member of the tyrosine, However, Overexpression of Vav or SLP-76 in Jurkat cells leads to NFAT activation and IL-2 production, The discovery of SLP-76 represents an important step in elucidating the mechanism of Vav transformation and TCR-mediated NFAT activation, Vav and SLP-76 synergize to induce a robust basal and TCR-mediated IL-2 response, Vav contains a single SH2 domain that is required for its association with the T cell receptor (TCR), When co-expressed, it does contain several putative SH2/SH3-binding domains and has been shown to physically associate with the adapter protein GRB2 as well as PLC g1, serine/threonine or lipid kinase families, the biochemical basis of Vavâ, &euro, &trade, The translational product of the Vav proto-oncogene is exclusively expressed in cells of hematopoietic origin and is critical for lymphocyte development and activation, s function is unclear
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names CG8697, LCP 2, LCP 2, LCP2, LCP2_HUMAN, Lymphocyte Cytosolic Protein 2, Lymphocyte Cytosolic Protein 2, SH2 Domain Containing Leukocyte Protein 76 KD, SH2 domain containing leukocyte protein of 76kD, SH2 domain containing leukocyte protein of 76kDa, SH2 domain-containing leukocyte protein of 76 kDa, SLP 76, SLP 76, SLP 76 tyrosine phosphoprotein, SLP-76 tyrosine phosphoprotein, SLP76, SLP76 tyrosine phosphoprotein, 76 kDa tyrosine phosphoprotein
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetSLP76
Short nameSLP76 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameSLP76 (Antibody to)
Alternative techniqueantibodies
Identity 6529
Gene LCP2
Long gene name lymphocyte cytosolic protein 2
Synonyms gene SLP76
Synonyms gene name lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76kD) lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
Synonyms SLP-76
Synonyms name 76 kDa tyrosine phosphoprotein SH2 domain-containing leukocyte protein of 76kD
Locus 5q35, 1
Discovery year 1996-03-12
Entrez gene record 3937
Pubmed identfication 7706237
RefSeq identity NM_005565
Classification SH2 domain containing
Havana BLAST/BLAT OTTHUMG00000163121

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