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SLUG Antibody

SLUG Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameSLUG Primary Polyclonal Antibody
Also known asSLUG PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenSLUG
SpecificityThis is a highly specific antibody against SLUG
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range1-50/268
Subcellular location Nucleus, Cytoplasm
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Slug
Gene ID number6591
Swiss ProtO43623
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts, Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes, Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, In epidermal keratinocytes, Involved in osteoblast maturation, Involved in the generation and migration of neural crest cells, Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes, Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis, Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells, Represses E-Cadherin/CDH1 transcription via E-box elements, binds to the E-box in ITGA3 promoter and represses its transcription, in osteoblasts, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity), respectively, Transcriptional repressor that modulates both activator-dependent and basal transcription
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names Neural crest transcription factor Slug, Protein snail homolog 2, SLUGH, SLUGH1, SNAI2, SNAIL2, WS2D, Zinc finger protein SNAI2, SLUG
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetSLUG
Short nameSLUG Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameSLUG (Antibody to)
Alternative techniqueantibodies
Identity 11094
Gene SNAI2
Long gene name snail family transcriptional repressor 2
Synonyms gene SLUG
Synonyms gene name slug homolog, zinc finger protein (chicken) snail homolog 2 (Drosophila) snail family zinc finger 2
Synonyms SLUGH1 SNAIL2 SLUGH
Locus 8q11, 21
Discovery year 1998-07-03
GenBank acession U97060
Entrez gene record 6591
Pubmed identfication 9337409 9721220
RefSeq identity NM_003068
Classification Zinc fingers C2H2-type SNAG transcriptional repressors
Havana BLAST/BLAT OTTHUMG00000149912

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