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Smac/DIABLO Antibody

Smac/DIABLO Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameSmac/DIABLO Primary Polyclonal Antibody
Also known asSmac/DIABLO PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenSmac/DIABLO
SpecificityThis is a highly specific antibody against Smac/DIABLO
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range177-211/239
Subcellular location Mitochondrion, Helical
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Smac
Gene ID number56616
Swiss ProtQ9NR28
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP), Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases, Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance, Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation, Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway, Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names DFNA64, DIABLO, Diablo homolog, Direct IAP-binding protein with low pI, Second mitochondria-derived activator of caspase, mitochondrial, SMAC
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetSmac/DIABLO
Short nameSmac/DIABLO Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative name IAP-binding mitochondrial protein (Antibody to), Smac/diablo
Alternative techniqueantibodies
Alternative to gene target DIABLO and IDBG-62263 and ENSG00000184047 and 56616, DIABLO and IDBG-632769 and ENSBTAG00000004199 and 493999, Diablo and IDBG-199693 and ENSMUSG00000029433 and 66593, IAP-binding mitochondrial protein, Plasma membranes, protein binding, this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005758 and mitochondrial intermembrane space and cellular component this GO :0005829 and cytosol and cellular component this GO :0006915 and apoptotic process and biological process this GO :0006919 and activation of cysteine-type endopeptidase activity involved in apoptotic process and biological process this GO :0008625 and extrinsic apoptotic signaling pathway via death domain receptors and biological process this GO :0008631 and intrinsic apoptotic signaling pathway in response to oxidative stress and biological process this GO :0008635 and activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c and biological process this GO :0009898 and cytoplasmic side of plasma membrane and cellular component this GO :0035631 and CD40 receptor complex and cellular component this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0051402 and neuron apoptotic process and biological process this GO :0097193 and intrinsic apoptotic signaling pathway and biological process, this GO :0005515: protein binding, this GO :0005515: protein binding, diablo
Identity 21528
Gene DIABLO
Long gene name diablo IAP-binding mitochondrial protein
Synonyms gene name IAP-binding mitochondrial protein , diablo
Synonyms SMAC DIABLO-S FLJ25049 FLJ10537 DFNA64
Synonyms name second mitochondria-derived activator of caspase
Locus 12q24, 31
Discovery year 2003-10-27
GenBank acession AF262240
Entrez gene record 56616
Pubmed identfication 12749848 17237824 21722859
RefSeq identity NM_019887
Classification Deafness associated genes
Havana BLAST/BLAT OTTHUMG00000157014

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