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Smad4 (26C4) Monoclonal Antibody

Smad4 (26C4) Monoclonal Antibody size: 0.1ml 362

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 362
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameSmad4 (26C4) Monoclonal Antibody
Also known asSmad4 (26C4) Monoclonal Antibody
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenSmad4
SpecificityThis is a highly specific antibody against Smad4
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityMonoclonal
Clone number26C4
Concentration1ug per 1ul
SourceRecombinant human protein purified from E, coli(His-Smad4)
Gene ID number4089
Swiss ProtQ13485
Tested Applications IP, WB
Recommended dilutions0 ug), 5 ug/mL) IP (2, WB (0
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression, Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions (By similarity), Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor), Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling, Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site, MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8, May act as a tumor suppressor, Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator, Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription, When recruited by MSTN, plays a central role in the balance between atrophy and hypertrophy, promotes atrophy response via phosphorylated SMAD2/4, required for synergistic transcriptional activity in response to TGF-beta, In muscle physiology
Purification methodPurified by Protein G
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names DPC4, Deletion target in pancreatic carcinoma 4, MAD homolog 4, MADH4, MYHRS, Mothers against DPP homolog 4, Mothers against decapentaplegic homolog 4, SMAD 4, SMAD family member 4, Smad4, hSMAD4, JIP
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
About Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones
Gene targetSmad4 (26C4) Monoclonal
Short nameSmad4 (26C4) Monoclonal Antibody
Technique Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody
Alternative nameSMAD family member 4 (26C4) monoclonal (Antibody to)
Alternative techniqueantibodies

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