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SMAD4 Antibody

SMAD4 Antibody size: 0.08 ml 199

Supplier NJS POLY
Price 199
Size 0.08 ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration pH 7, with 0, 09% sodium azide, 4, In 1X PBS
FormAntigen affinity purified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenSMAD4
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications ELISA, IF, WB
Recommended dilutionsImmunofluorescence: 1:10-1:50, Western blot: 1:1000
NotesTitration of the SMAD4 antibody may be required due to differences in protocols and secondary/substrate sensitivity
Intented useThis SMAD4 antibodyis to be used only for research purposes and not for diagnostics
Uniprot #Q13485
PurityAntigen affinity
Description It may act as a tumor suppressor, It promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription, SMAD4 is the common SMAD (co-SMAD)mediator of signal transduction by TGF-beta (transforming growth factor)
ImmunogenA portion of amino acids 255-284 from the human protein was used as the immunogen for this SMAD4 antibody
Storage Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the SMAD4 antibody and store frozen at -20 deg
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetSMAD4
Short nameSMAD4 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameSMAD family member 4 (Antibody to)
Alternative techniqueantibodies
Alternative to gene target DNA-templated and biological process this GO :0006355 and regulation of transcription, DNA-templated and biological process this GO :0006357 and regulation of transcription from RNA polymerase II promoter and biological process this GO :0006366 and transcription from RNA polymerase II promoter and biological process this GO :0006367 and transcription initiation from RNA polymerase II promoter and biological process this GO :0007179 and transforming growth factor beta receptor signaling pathway and biological process this GO :0007183 and SMAD protein complex assembly and biological process this GO :0007369 and gastrulation and biological process this GO :0007411 and axon guidance and biological process this GO :0007492 and endoderm development and biological process this GO :0007498 and mesoderm development and biological process this GO :0008283 and cell proliferation and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0009952 and anterior/posterior pattern specification and biological process this GO :0010467 and gene expression and biological process this GO :0010718 and positive regulation of epithelial to mesenchymal transition and biological process this GO :0010862 and positive regulation of pathway-restricted SMAD protein phosphorylation and biological process this GO :0014033 and neural crest cell differentiation and biological process this GO :0017015 and regulation of transforming growth factor beta receptor signaling pathway and biological process this GO :0030308 and negative regulation of cell growth and biological process this GO :0030509 and BMP signaling pathway and biological process this GO :0030511 and positive regulation of transforming growth factor beta receptor signaling pathway and biological process this GO :0030513 and positive regulation of BMP signaling pathway and biological process this GO :0030616 and transforming growth factor beta receptor, DNA-templated and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046872 and metal ion binding and molecular function this GO :0048589 and developmental growth and biological process this GO :0048663 and neuron fate commitment and biological process this GO :0048729 and tissue morphogenesis and biological process this GO :0048733 and sebaceous gland development and biological process this GO :0048859 and formation of anatomical boundary and biological process this GO :0051098 and regulation of binding and biological process this GO :0051797 and regulation of hair follicle development and biological process this GO :0060021 and palate development and biological process this GO :0060391 and positive regulation of SMAD protein import into nucleus and biological process this GO :0060395 and SMAD protein signal transduction and biological process this GO :0060548 and negative regulation of cell death and biological process this GO :0060956 and endocardial cell differentiation and biological process this GO :0070411 and I-SMAD binding and molecular function this GO :0070412 and R-SMAD binding and molecular function this GO :0071141 and SMAD protein complex and cellular component this GO :0071559 and response to transforming growth factor beta and biological process this GO :0072133 and metanephric mesenchyme morphogenesis and biological process this GO :0072134 and nephrogenic mesenchyme morphogenesis and biological process, DPC4 and JIP and MADH4 and MYHRS, SMAD4 and IDBG-3485 and ENSG00000141646 and 4089, SMAD4 and IDBG-644730 and ENSBTAG00000006919 and 540248, Smad4 and IDBG-157503 and ENSMUSG00000024515 and 17128, common-partner cytoplasmic mediator activity, common-partner cytoplasmic mediator activity and also this GO :0042802: identical protein binding and also this GO :0042803: protein homodimerization activity and also this GO :0043565: sequence-specific DNA binding and also this GO :0044212: transcription regulatory region DNA binding and also this GO :0046872: metal ion binding and also this GO :0070411: I-SMAD binding and also this GO :0070412: R-SMAD binding, common-partner cytoplasmic mediator activity and molecular function this GO :0032444 and activin responsive factor complex and cellular component this GO :0032525 and somite rostral/caudal axis specification and biological process this GO :0032909 and regulation of transforming growth factor beta2 production and biological process this GO :0035556 and intracellular signal transduction and biological process this GO :0036302 and atrioventricular canal development and biological process this GO :0042118 and endothelial cell activation and biological process this GO :0042127 and regulation of cell proliferation and biological process this GO :0042177 and negative regulation of protein catabolic process and biological process this GO :0042802 and identical protein binding and molecular function this GO :0042803 and protein homodimerization activity and molecular function this GO :0043565 and sequence-specific DNA binding and molecular function this GO :0044212 and transcription regulatory region DNA binding and molecular function this GO :0045087 and innate immune response and biological process this GO :0045892 and negative regulation of transcription, nuclei, this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0000790 and nuclear chromatin and cellular component this GO :0000987 and core promoter proximal region sequence-specific DNA binding and molecular function this GO :0000988 and protein binding transcription factor activity and molecular function this GO :0001076 and RNA polymerase II transcription factor binding transcription factor activity and molecular function this GO :0001085 and RNA polymerase II transcription factor binding and molecular function this GO :0001658 and branching involved in ureteric bud morphogenesis and biological process this GO :0001666 and response to hypoxia and biological process this GO :0001701 and in utero embryonic development and biological process this GO :0001702 and gastrulation with mouth forming second and biological process this GO :0001822 and kidney development and biological process this GO :0003190 and atrioventricular valve formation and biological process this GO :0003198 and epithelial to mesenchymal transition involved in endocardial cushion formation and biological process this GO :0003251 and positive regulation of cell proliferation involved in heart valve morphogenesis and biological process this GO :0003279 and cardiac septum development and biological process this GO :0003360 and brainstem development and biological process this GO :0003677 and DNA binding and molecular function this GO :0003682 and chromatin binding and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005518 and collagen binding and molecular function this GO :0005622 and intracellular and cellular component this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005667 and transcription factor complex and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005813 and centrosome and cellular component this GO :0005829 and cytosol and cellular component this GO :0006351 and transcription, this GO :0000987: core promoter proximal region sequence-specific DNA binding, this GO :0000987: core promoter proximal region sequence-specific DNA binding and also this GO :0000988: protein binding transcription factor activity and also this GO :0001076: RNA polymerase II transcription factor binding transcription factor activity and also this GO :0001085: RNA polymerase II transcription factor binding and also this GO :0003677: DNA binding and also this GO :0003682: chromatin binding and also this GO :0003700: sequence-specific DNA binding transcription factor activity and also this GO :0005515: protein binding and also this GO :0005518: collagen binding and also this GO :0030616: transforming growth factor beta receptor, this GO :0000988: protein binding transcription factor activity, this GO :0001076: RNA polymerase II transcription factor binding transcription factor activity, this GO :0001085: RNA polymerase II transcription factor binding, this GO :0003677: DNA binding, this GO :0003682: chromatin binding, this GO :0003700: sequence-specific DNA binding transcription factor activity, this GO :0005515: protein binding, this GO :0005518: collagen binding, this GO :0030616: transforming growth factor beta receptor, this GO :0042802: identical protein binding, this GO :0042803: protein homodimerization activity, this GO :0043565: sequence-specific DNA binding, this GO :0044212: transcription regulatory region DNA binding, this GO :0046872: metal ion binding, this GO :0070411: I-SMAD binding, this GO :0070412: R-SMAD binding, transforming growth factor beta receptor, SMAD family member 4
Identity 6770
Gene SMAD4
Long gene name SMAD family member 4
Synonyms gene MADH4
Synonyms gene name MAD, mothers against DPP homolog 4 (Drosophila) , mothers against decapentaplegic homolog 4 (Drosophila) SMAD
Synonyms DPC4
Locus 18q21, 2
Discovery year 1996-11-15
GenBank acession U44378
Entrez gene record 4089
Pubmed identfication 8553070 8774881
RefSeq identity NM_005359
Classification SMAD family
Havana BLAST/BLAT OTTHUMG00000132696
Locus Specific Databases LRG_318

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