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SNX2 Antibody, Biotin Conjugated

SNX2 Antibody, Biotin Conjugated size: 0.1ml 333

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 333
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Biotin Conjugated, SNX2 Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationBiotinylated
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenSNX2
SpecificityThis is a highly specific antibody against SNX2
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range145-195/519
Subcellular locationMembrane bound
SourceKLH conjugated synthetic peptide derived from human SNX2
Gene ID number6643
Swiss ProtO60749
Tested applications IHC-P, WB
Recommended dilutions IHC-P(1:100-500), WB(1:100-1000)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:17101778), Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:23085988), Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3, Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation, Required for retrograde endosome-to-TGN transport of TGN38 (PubMed:20138391), The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling, The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable), the function is dependent on GEF activity of KALRN (PubMed:20604901), 5)P2) (PubMed:16179610), 5-bisphosphate (PtdIns(3, Involved in several stages of intracellular trafficking
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation EmissionN/A
Properties Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetSNX2 Conjugated
Short name Conjugated, SNX2 Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelBiotin
Alternative name biotinilated coupled, sorting nexin 2 (Antibody to)
Alternative techniqueantibodies
Alternative to gene target BT, Cytoplasm, SNX2 and IDBG-38906 and ENSG00000205302 and 6643, Snx2 and IDBG-146883 and ENSMUSG00000034484 and 67804, TRG-9, phosphatidylinositol binding, this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0006886 and intracellular protein transport and biological process this GO :0006897 and endocytosis and biological process this GO :0010008 and endosome membrane and cellular component this GO :0016023 and cytoplasmic membrane-bounded vesicle and cellular component this GO :0030904 and retromer complex and cellular component this GO :0031901 and early endosome membrane and cellular component this GO :0035091 and phosphatidylinositol binding and molecular function this GO :0043231 and intracellular membrane-bounded organelle and cellular component this GO :0070062 and extracellular vesicular exosome and cellular component, this GO :0005515: protein binding, this GO :0005515: protein binding and also this GO :0035091: phosphatidylinositol binding, this GO :0035091: phosphatidylinositol binding, 26946 and IDBG-644960 and ENSBTAG00000025358 and 509769, sorting nexin 2
Identity 11173
Gene SNX2
Long gene name sorting nexin 2
Locus 5q23, 2
Discovery year 1996-07-17
GenBank acession AF043453
Entrez gene record 6643
Pubmed identfication 9819414
RefSeq identity NM_003100
Classification Sorting nexins PX-BAR domain containing
Havana BLAST/BLAT OTTHUMG00000163020

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