| Long name | SOCS1 Primary Polyclonal Antibody |
| Also known as | SOCS1 PAb |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | SOCS1 |
| Specificity | This is a highly specific antibody against SOCS1 |
| Modification(s) | None |
| Modification site(s) | Unmodified antibody |
| Clonality | Polyclonal antibody |
| Clone number | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Immunogen range | 160-211/211 |
| Subcellular location | Nucleus |
| Source | This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Socs 1 |
| Gene ID number | 8651 |
| Swiss Prot | O15524 |
| Tested Applications | IF(IHC-P), IHC-P, WB |
| Recommended dilutions | IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity | Mouse, Rat, Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF), In vitro, Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, Regulates interferon-gamma mediated sensory neuron survival (By similarity), SOCS1 appears to be a negative regulator in IGF1R signaling pathway, SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway, Seems to recognize JAK2, Through binding to JAKs, also suppresses Tec protein-tyrosine activity, inhibits their kinase activity, SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction |
| Purification method | This antibody was purified via Protein A |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | CIS1, CISH1, JAK-binding protein, SOCS-1, SOCS1, SSI-1, SSI1, STAT-induced STAT inhibitor 1, Suppressor of cytokine signaling 1, TIP-3, TIP3, Tec-interacting protein 3, JAB |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target | SOCS1 |
| Short name | SOCS1 Antibody |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Alternative name | suppressor on cytokine signaling 1 (Antibody to) |
| Alternative technique | antibodies |
| Alternative to gene target | CIS1 and CISH1 and JAB and SOCS-1 and SSI-1 and SSI1 and TIP3, SOCS1 and IDBG-14621 and ENSG00000185338 and 8651, SOCS1 and IDBG-648701 and ENSBTAG00000004386 and 518795, Socs1 and IDBG-132667 and ENSMUSG00000038037 and 12703, nuclei, protein kinase binding, this GO :0001932 and regulation of protein phosphorylation and biological process this GO :0004860 and protein kinase inhibitor activity and molecular function this GO :0005159 and insulin-like growth factor receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006469 and negative regulation of protein kinase activity and biological process this GO :0007259 and JAK-STAT cascade and biological process this GO :0016023 and cytoplasmic membrane-bounded vesicle and cellular component this GO :0016567 and protein ubiquitination and biological process this GO :0019210 and kinase inhibitor activity and molecular function this GO :0019221 and cytokine-mediated signaling pathway and biological process this GO :0019901 and protein kinase binding and molecular function this GO :0035556 and intracellular signal transduction and biological process this GO :0040008 and regulation of growth and biological process this GO :0042518 and negative regulation of tyrosine phosphorylation of Stat3 protein and biological process this GO :0045087 and innate immune response and biological process this GO :0045444 and fat cell differentiation and biological process this GO :0046426 and negative regulation of JAK-STAT cascade and biological process this GO :0046627 and negative regulation of insulin receptor signaling pathway and biological process this GO :0060333 and interferon-gamma-mediated signaling pathway and biological process this GO :0060334 and regulation of interferon-gamma-mediated signaling pathway and biological process this GO :0060337 and type I interferon signaling pathway and biological process this GO :0060338 and regulation of type I interferon-mediated signaling pathway and biological process this GO :0060397 and JAK-STAT cascade involved in growth hormone signaling pathway and biological process this GO :0071230 and cellular response to amino acid stimulus and biological process, this GO :0004860: protein kinase inhibitor activity, this GO :0004860: protein kinase inhibitor activity and also this GO :0005159: insulin-like growth factor receptor binding and also this GO :0005515: protein binding and also this GO :0019210: kinase inhibitor activity and also this GO :0019901: protein kinase binding, this GO :0005159: insulin-like growth factor receptor binding, this GO :0005515: protein binding, this GO :0019210: kinase inhibitor activity, this GO :0019901: protein kinase binding, suppressor of cytokine signaling 1 |
| Identity | 19383 |
| Gene | SOCS1 |
| Long gene name | suppressor of cytokine signaling 1 |
| Synonyms | SOCS-1 SSI-1 JAB TIP3 Cish1 |
| Locus | 16p13, 13 |
| Discovery year | 2002-11-13 |
| GenBank acession | U88326 |
| Pubmed identfication | 7796808 9266833 |
| Classification | Suppressors of cytokine signaling SH2 domain containing |
| Havana BLAST/BLAT | OTTHUMG00000129792 |
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