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SOCS1 Antibody, ALEXA FLUOR 488

SOCS1 Antibody, ALEXA FLUOR 488 size: 100ul 332

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES
Price 332
Size 100ul
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name ALEXA FLUOR 488 Conjugated, SOCS1 Polyclonal Antibody
Also known asAnti-SOCS1 PAb ALEXA FLUOR 488
CategoryConjugated Primary Antibodies
Conjugated with 488, ALEXA FLUOR®
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenSOCS1
SpecificityThis is a highly specific antibody against SOCS1
ModificationUnmodified
Modification SiteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen range160-211/211
Subcellular locationNucleus
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Socs 1
Gene ID Number8651
Swiss ProtO15524
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Cross-reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF), In vitro, Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, Regulates interferon-gamma mediated sensory neuron survival (By similarity), SOCS1 appears to be a negative regulator in IGF1R signaling pathway, SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway, Seems to recognize JAK2, Through binding to JAKs, also suppresses Tec protein-tyrosine activity, inhibits their kinase activity, SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction
PurificationPurified by Protein A
Storage conditions 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission499nm/519nm
Synonyms SOCS-1 SSI-1 JAB TIP3 Cish1
Properties ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the SOCS1 Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
Gene targetSOCS1
Short nameSOCS1 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
LabelALEXA FLUOR 488
Alternative name ALEXA FLUOR 488, suppressor on cytokine signaling 1 (Antibody to)
Alternative techniqueantibodies
Alternative to gene target CIS1 and CISH1 and JAB and SOCS-1 and SSI-1 and SSI1 and TIP3, SOCS1 and IDBG-14621 and ENSG00000185338 and 8651, SOCS1 and IDBG-648701 and ENSBTAG00000004386 and 518795, Socs1 and IDBG-132667 and ENSMUSG00000038037 and 12703, nuclei, protein kinase binding, this GO :0001932 and regulation of protein phosphorylation and biological process this GO :0004860 and protein kinase inhibitor activity and molecular function this GO :0005159 and insulin-like growth factor receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006469 and negative regulation of protein kinase activity and biological process this GO :0007259 and JAK-STAT cascade and biological process this GO :0016023 and cytoplasmic membrane-bounded vesicle and cellular component this GO :0016567 and protein ubiquitination and biological process this GO :0019210 and kinase inhibitor activity and molecular function this GO :0019221 and cytokine-mediated signaling pathway and biological process this GO :0019901 and protein kinase binding and molecular function this GO :0035556 and intracellular signal transduction and biological process this GO :0040008 and regulation of growth and biological process this GO :0042518 and negative regulation of tyrosine phosphorylation of Stat3 protein and biological process this GO :0045087 and innate immune response and biological process this GO :0045444 and fat cell differentiation and biological process this GO :0046426 and negative regulation of JAK-STAT cascade and biological process this GO :0046627 and negative regulation of insulin receptor signaling pathway and biological process this GO :0060333 and interferon-gamma-mediated signaling pathway and biological process this GO :0060334 and regulation of interferon-gamma-mediated signaling pathway and biological process this GO :0060337 and type I interferon signaling pathway and biological process this GO :0060338 and regulation of type I interferon-mediated signaling pathway and biological process this GO :0060397 and JAK-STAT cascade involved in growth hormone signaling pathway and biological process this GO :0071230 and cellular response to amino acid stimulus and biological process, this GO :0004860: protein kinase inhibitor activity, this GO :0004860: protein kinase inhibitor activity and also this GO :0005159: insulin-like growth factor receptor binding and also this GO :0005515: protein binding and also this GO :0019210: kinase inhibitor activity and also this GO :0019901: protein kinase binding, this GO :0005159: insulin-like growth factor receptor binding, this GO :0005515: protein binding, this GO :0019210: kinase inhibitor activity, this GO :0019901: protein kinase binding, suppressor of cytokine signaling 1
Identity 19383
Gene SOCS1
Long gene name suppressor of cytokine signaling 1
Locus 16p13, 13
Discovery year 2002-11-13
GenBank acession U88326
Pubmed identfication 7796808 9266833
Classification Suppressors of cytokine signaling SH2 domain containing
Havana BLAST/BLAT OTTHUMG00000129792

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