| Long name | SOX2 Primary Polyclonal Antibody |
| Also known as | SOX2 PAb |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | SOX2 |
| Specificity | This is a highly specific antibody against SOX2 |
| Modification(s) | None |
| Modification site(s) | Unmodified antibody |
| Clonality | Polyclonal antibody |
| Clone number | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Immunogen range | 230-280/319 |
| Subcellular location | Nucleus |
| Source | KLH conjugated synthetic peptide derived from mouse Transcription factor SOX-2 |
| Gene ID number | 20674 |
| Swiss Prot | P48432 |
| Tested Applications | FCM, IF(ICC), IF(IHC-P), IHC-P, WB |
| Recommended dilutions | FCM(1:20-100), IF(ICC)(1:50-200), IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity | Mouse, Rat, Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | Critical for early embryogenesis and for embryonic stem cell pluripotency, Downstream SRRT target that mediates the promotion of neural stem cell self-renewal, FGF4, Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity), May function as a switch in neuronal development, UTF1 and ZFP26, Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1 |
| Purification method | This antibody was purified via Protein A |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | Sox-2, Sox2, Transcription factor SOX-2, ysb, lcc |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target | SOX2 |
| Short name | SOX2 Antibody |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Alternative name | SRY (sex determining region Y)-box 2 (Antibody to) |
| Alternative technique | antibodies |
| Alternative to gene target | ANOP3 and MCOPS3, DNA-templated and biological process this GO :0006355 and regulation of transcription, DNA-templated and biological process this GO :0006357 and regulation of transcription from RNA polymerase II promoter and biological process this GO :0006366 and transcription from RNA polymerase II promoter and biological process this GO :0007050 and cell cycle arrest and biological process this GO :0007605 and sensory perception of sound and biological process this GO :0009611 and response to wounding and biological process this GO :0010033 and response to organic substance and biological process this GO :0010468 and regulation of gene expression and biological process this GO :0019827 and stem cell maintenance and biological process this GO :0021781 and glial cell fate commitment and biological process this GO :0021879 and forebrain neuron differentiation and biological process this GO :0021983 and pituitary gland development and biological process this GO :0021984 and adenohypophysis development and biological process this GO :0021987 and cerebral cortex development and biological process this GO :0022409 and positive regulation of cell-cell adhesion and biological process this GO :0030178 and negative regulation of Wnt signaling pathway and biological process this GO :0030539 and male genitalia development and biological process this GO :0030858 and positive regulation of epithelial cell differentiation and biological process this GO :0030900 and forebrain development and biological process this GO :0030910 and olfactory placode formation and biological process this GO :0032526 and response to retinoic acid and biological process this GO :0035019 and somatic stem cell maintenance and biological process this GO :0035198 and miRNA binding and molecular function this GO :0042246 and tissue regeneration and biological process this GO :0042472 and inner ear morphogenesis and biological process this GO :0043281 and regulation of cysteine-type endopeptidase activity involved in apoptotic process and biological process this GO :0043410 and positive regulation of MAPK cascade and biological process this GO :0043565 and sequence-specific DNA binding and molecular function this GO :0043586 and tongue development and biological process this GO :0044212 and transcription regulatory region DNA binding and molecular function this GO :0044798 and nuclear transcription factor complex and cellular component this GO :0045165 and cell fate commitment and biological process this GO :0045596 and negative regulation of cell differentiation and biological process this GO :0045597 and positive regulation of cell differentiation and biological process this GO :0045665 and negative regulation of neuron differentiation and biological process this GO :0045666 and positive regulation of neuron differentiation and biological process this GO :0045668 and negative regulation of osteoblast differentiation and biological process this GO :0045747 and positive regulation of Notch signaling pathway and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046148 and pigment biosynthetic process and biological process this GO :0046982 and protein heterodimerization activity and molecular function this GO :0048286 and lung alveolus development and biological process this GO :0048568 and embryonic organ development and biological process this GO :0048646 and anatomical structure formation involved in morphogenesis and biological process this GO :0048663 and neuron fate commitment and biological process this GO :0048839 and inner ear development and biological process this GO :0048852 and diencephalon morphogenesis and biological process this GO :0048863 and stem cell differentiation and biological process this GO :0050680 and negative regulation of epithelial cell proliferation and biological process this GO :0050767 and regulation of neurogenesis and biological process this GO :0050910 and detection of mechanical stimulus involved in sensory perception of sound and biological process this GO :0050973 and detection of mechanical stimulus involved in equilibrioception and biological process this GO :0060042 and retina morphogenesis in camera-type eye and biological process this GO :0060235 and lens induction in camera-type eye and biological process this GO :0060441 and epithelial tube branching involved in lung morphogenesis and biological process this GO :0070848 and response to growth factor and biological process this GO :0090090 and negative regulation of canonical Wnt signaling pathway and biological process this GO :0097150 and neuronal stem cell maintenance and biological process, SOX2 and IDBG-647279 and ENSBTAG00000011598 and 784383, SOX2 and IDBG-66692 and ENSG00000181449 and 6657, Sox2 and IDBG-137912 and ENSMUSG00000074637 and 20674, nuclei, protein heterodimerization activity, this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0000976 and transcription regulatory region sequence-specific DNA binding and molecular function this GO :0000981 and sequence-specific DNA binding RNA polymerase II transcription factor activity and molecular function this GO :0001077 and RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription and molecular function this GO :0001649 and osteoblast differentiation and biological process this GO :0001654 and eye development and biological process this GO :0001708 and cell fate specification and biological process this GO :0001714 and endodermal cell fate specification and biological process this GO :0002052 and positive regulation of neuroblast proliferation and biological process this GO :0003677 and DNA binding and molecular function this GO :0003682 and chromatin binding and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005667 and transcription factor complex and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006325 and chromatin organization and biological process this GO :0006351 and transcription, this GO :0000976: transcription regulatory region sequence-specific DNA binding, this GO :0000976: transcription regulatory region sequence-specific DNA binding and also this GO :0000981: sequence-specific DNA binding RNA polymerase II transcription factor activity and also this GO :0001077: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription and also this GO :0003677: DNA binding and also this GO :0003682: chromatin binding and also this GO :0003700: sequence-specific DNA binding transcription factor activity and also this GO :0005515: protein binding and also this GO :0035198: miRNA binding and also this GO :0043565: sequence-specific DNA binding and also this GO :0044212: transcription regulatory region DNA binding and also this GO :0046982: protein heterodimerization activity, this GO :0000981: sequence-specific DNA binding RNA polymerase II transcription factor activity, this GO :0001077: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription, this GO :0003677: DNA binding, this GO :0003682: chromatin binding, this GO :0003700: sequence-specific DNA binding transcription factor activity, this GO :0005515: protein binding, this GO :0035198: miRNA binding, this GO :0043565: sequence-specific DNA binding, this GO :0044212: transcription regulatory region DNA binding, this GO :0046982: protein heterodimerization activity, SRY (sex determining region Y)-box 2 |
| Identity | 11195 |
| Gene | SOX2 |
| Long gene name | SRY-box 2 |
| Synonyms gene name | SRY (sex determining region Y)-box 2 SRY box 2 |
| Locus | 3q26, 33 |
| Discovery year | 1993-11-30 |
| GenBank acession | BC013923 |
| Entrez gene record | 6657 |
| Pubmed identfication | 7849401 |
| RefSeq identity | NM_003106 |
| Classification | SRY-boxes |
| Havana BLAST/BLAT | OTTHUMG00000158222 |
| Locus Specific Databases | LOVD LRG_719 |
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