| Long name | SP3 Primary Polyclonal Antibody |
| Also known as | SP3 PAb |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | SP3 |
| Specificity | This is a highly specific antibody against SP3 |
| Modification(s) | None |
| Modification site(s) | Unmodified antibody |
| Clonality | Polyclonal antibody |
| Clone number | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Source | This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human SP3 |
| Tested Applications | IF(IHC-P), IHC-P, WB |
| Recommended dilutions | IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity | Mouse, Rat, Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | All four proteins contain a highly conserved DNA-binding domain composed of three zinc fingers at the C-terminus, Sp family members bind the consensus sequence GGGGCGGGGC and other closely related sequences which are known as GC boxes, Sp transcription factors share similar structures but do not share simi-lar functions, Sp1, Sp1, Sp1 and Sp3, Sp2, Sp2 and Sp3 are ubiquitously expressed, Sp2 only weakly binds to GT boxes, Sp3 (SPR-2) and Sp4 (SPR-1), Sp3 and Sp4 share a high affinity for GC boxes while Sp2 does not, Sp3 is the only Sp member to inhibit Sp1 and Sp4 media, a regulatory element for the â, but not Sp2 or Sp4, interact with E2, while Sp4 is abundantly expressed in brain with limited expression in other tissues, &circ, «, 4 subunit of neuronal nicotinic acetylcholine receptors, The Sp transcription factor family includes Sp1 |
| Purification method | This antibody was purified via Protein A |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | DKFZp686O1631, GC binding transcription factor Sp 3, GC binding transcription factor Sp3, MGC105187, OTTMUSP00000014207, SP 3, SP3, SP3_HUMAN, SPR 2, SPR-2, SPR2, Sp 3 transcription factor, Sp3 transcription factor, Specicity protein 3, Transcription factor SP 3, Transcription factor SP3, Transcription factor Sp3, D130027J01Rik |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target | SP3 |
| Short name | SP3 Antibody |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Alternative name | Sp3 transcription factor (Antibody to) |
| Alternative technique | antibodies |
| Alternative to gene target | DNA-templated and biological process this GO :0006355 and regulation of transcription, DNA-templated and biological process this GO :0016605 and PML body and cellular component this GO :0017053 and transcriptional repressor complex and cellular component this GO :0030183 and B cell differentiation and biological process this GO :0030217 and T cell differentiation and biological process this GO :0030218 and erythrocyte differentiation and biological process this GO :0030219 and megakaryocyte differentiation and biological process this GO :0030224 and monocyte differentiation and biological process this GO :0030324 and lung development and biological process this GO :0030851 and granulocyte differentiation and biological process this GO :0043353 and enucleate erythrocyte differentiation and biological process this GO :0045892 and negative regulation of transcription, DNA-templated and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0046872 and metal ion binding and molecular function this GO :0048596 and embryonic camera-type eye morphogenesis and biological process this GO :0048706 and embryonic skeletal system development and biological process this GO :0060136 and embryonic process involved in female pregnancy and biological process this GO :0060216 and definitive hemopoiesis and biological process, SP3 and IDBG-640536 and ENSBTAG00000000176 and 540766, SP3 and IDBG-75293 and ENSG00000172845 and 6670, SPR2, Sp3 and IDBG-179756 and ENSMUSG00000027109 and 20687, metal ion binding, nuclei, this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0000979 and RNA polymerase II core promoter sequence-specific DNA binding and molecular function this GO :0000987 and core promoter proximal region sequence-specific DNA binding and molecular function this GO :0001078 and RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription and molecular function this GO :0001503 and ossification and biological process this GO :0001701 and in utero embryonic development and biological process this GO :0001779 and natural killer cell differentiation and biological process this GO :0001829 and trophectodermal cell differentiation and biological process this GO :0001889 and liver development and biological process this GO :0001892 and embryonic placenta development and biological process this GO :0003677 and DNA binding and molecular function this GO :0003682 and chromatin binding and molecular function this GO :0003690 and double-stranded DNA binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0006351 and transcription, this GO :0000979: RNA polymerase II core promoter sequence-specific DNA binding, this GO :0000979: RNA polymerase II core promoter sequence-specific DNA binding and also this GO :0000987: core promoter proximal region sequence-specific DNA binding and also this GO :0001078: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription and also this GO :0003677: DNA binding and also this GO :0003682: chromatin binding and also this GO :0003690: double-stranded DNA binding and also this GO :0005515: protein binding and also this GO :0046872: metal ion binding, this GO :0000987: core promoter proximal region sequence-specific DNA binding, this GO :0001078: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription, this GO :0003677: DNA binding, this GO :0003682: chromatin binding, this GO :0003690: double-stranded DNA binding, this GO :0005515: protein binding, this GO :0046872: metal ion binding, Sp3 transcription factor |
| Identity | 11208 |
| Gene | SP3 |
| Long gene name | Sp3 transcription factor |
| Synonyms | SPR-2 |
| Locus | 2q31, 1 |
| Discovery year | 1993-02-10 |
| GenBank acession | M97191 |
| Entrez gene record | 6670 |
| Pubmed identfication | 1341900 1454515 |
| RefSeq identity | NM_003111 |
| Classification | Sp transcription factors Zinc fingers C2H2-type |
| Havana BLAST/BLAT | OTTHUMG00000132333 |
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