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SPG3A/Atlastin Antibody, Biotin Conjugated

SPG3A/Atlastin Antibody, Biotin Conjugated size: 0.1ml 333

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 333
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Biotin Conjugated, SPG3A/Atlastin Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationBiotinylated
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenSPG3A/Atlastin
SpecificityThis is a highly specific antibody against SPG3A/Atlastin
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
SourceKLH conjugated synthetic peptide derived from human SPG3A/Atlastin
Tested applications IHC-P, WB
Recommended dilutions IHC-P(1:100-500), WB(1:100-1000)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background HSP primarily affects long corticospinal neurons and causes spastic lower extremity weakness, Hereditary spastic paraplegia (HSP) is an inherited neurodegenerative disorder that is characterized by retrograde axonal degeneration, Mutations in the Atlastin gene (SPG3A) account for approximately 10% of all autosomal dominant HSPs, Spastin, The Atlastin proteins, This Spastin/Atlastin binding may be involved in the biochemical pathway that leads to HSP development, a microtubule (MT)-severing AAA ATPase, also designated SPG3A and guanylate-binding protein 3, comprise a Dynamin superfamily that plays a role in axonal maintenance, integral membrane proteins that function as GTPases, is a binding partner of Atlastin that is involved in membrane dynamics, while mutations in the Spastin gene (SPG4) account for almost 40%, Atlastins are Golgi-localized
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation EmissionN/A
Synonyms FSP1 AD-FSP
Properties Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetSPG3A/Atlastin Conjugated
Short name Conjugated, SPG3A/Atlastin Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelBiotin
Alternative name biotinilated coupled, SPG3A/Atlastin (Antibody to)
Alternative techniqueantibodies
Identity 11231
Gene ATL1
Long gene name atlastin GTPase 1
Synonyms gene SPG3 SPG3A
Synonyms gene name spastic paraplegia 3A (autosomal dominant)
Synonyms name atlastin
Locus 14q22, 1
Discovery year 1993-10-28
GenBank acession AF131801
Entrez gene record 51062
Pubmed identfication 8252041 7825576
Havana BLAST/BLAT OTTHUMG00000140297
Locus Specific Databases LRG_360

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