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SPR/Sepiapterin reductase Antibody

SPR/Sepiapterin reductase Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameSPR/Sepiapterin reductase Antibody
Also known asSPR/Sepiapterin reductase Antibody
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenSPR/Sepiapterin reductase
SpecificityThis is a highly specific antibody against SPR/Sepiapterin reductase
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Sepiapterin reductase
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen BH4 is an essential cofactor for the hydroxylation of the aromatic amino acids (tryptophan, In addition, In addition, Mutations in the gene encoding SPR can cause sepiapterin reductase deficiency, SPR functions as an NADH-dependent aldo-keto reductase and specifically catalyzes the reduction of pteridine derivatives, SPR mRNA expression is increased in the brain of Parkinsonâ, SPR plays an important role in tetrahydrobiopterin (BH4) biosynthesis, Sepiapterin reductase deficiency interferes with BH4 synthesis, a monoamine neurotransmitter deficiency without hyperphenylalaninemia, also known as sepiapterin reductase, catalyzing the final reduction step of the synthesis pathway, is a homodimeric cytoplasmic protein that belongs to the sepiapterin reductase family, resulting in DOPA-responsive dystonia and a variety of other human diseases, suggesting that SPR may play a role in PD, tyrosine and phenylalanine) and is required for proper dopamine synthesis, &euro, &trade, SPR, s Disease (PD) patients
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names SPR, SPRE_HUMAN, Sepiapterin reductase, Sepiapterin reductase 7, Short chain dehydrogenase/reductase family 38C, member 1, 8 dihydrobiopterin:NADP+ oxidoreductase, SDR38C1
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetSPR/Sepiapterin reductase
Short nameSPR/Sepiapterin reductase Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameSPR/Sepiapterin reductase (Antibody to)
Alternative techniqueantibodies
Identity 11257
Gene SPR
Long gene name sepiapterin reductase (7, 8-dihydrobiopterin:NADP+ oxidoreductase)
Synonyms SDR38C1
Synonyms name member 1 , short chain dehydrogenase/reductase family 38C
Locus 2p13, 2
Discovery year 1991-12-05
Entrez gene record 6697
Pubmed identfication 1883349 19027726
Classification Short chain dehydrogenase/reductase superfamily
Havana BLAST/BLAT OTTHUMG00000129777
Locus Specific Databases BIOMBD

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