| Long name | SQSTM1 Primary Polyclonal Antibody |
| Also known as | SQSTM1 PAb |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | SQSTM1 |
| Specificity | This is a highly specific antibody against SQSTM1 |
| Modification(s) | None |
| Modification site(s) | Unmodified antibody |
| Clonality | Polyclonal antibody |
| Clone number | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Immunogen range | 80-130/440 |
| Subcellular location | Nucleus, Cytoplasm |
| Source | This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human SQSTM1/Ubiquitin-binding protein p62 |
| Gene ID number | 8878 |
| Swiss Prot | Q13501 |
| Tested Applications | IF(IHC-P), IHC-P, WB |
| Recommended dilutions | IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity | Mouse, Rat, Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | Adapter that mediates the interaction between TRAF6 and CYLD (By similarity), Involved in midbody ring degradation, May be involved in cell differentiation, May play a role in titin/TTN downstream signaling in muscle cells, May regulate signaling cascades through ubiquitination, May regulate the activation of NFKB1 by TNF-alpha, Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, apoptosis, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery, immune response and regulation of K(+) channels, nerve growth factor (NGF) and interleukin-1, Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family |
| Purification method | This antibody was purified via Protein A |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | A170, EBI3-associated protein of 60 kDa, EBIAP, ORCA, OSIL, PDB3, Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa, SQSTM1, Sequestosome-1, Ubiquitin-binding protein p62, ZIP3, p62, p62B, p60 |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target | SQSTM1 |
| Short name | SQSTM1 Antibody |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Alternative name | sequestosome 1 (Antibody to) |
| Alternative technique | antibodies |
| Alternative to gene target | A170 and OSIL and p60 and p62 and p62B and PDB3 and ZIP3, BT, K63-linked polyubiquitin binding, SQSTM1 and IDBG-61811 and ENSG00000161011 and 8878, Sqstm1 and IDBG-168358 and ENSMUSG00000015837 and 18412, nuclei, this GO :0000407 and pre-autopha this GO somal structure and cellular component this GO :0000932 and cytoplasmic mRNA processing body and cellular component this GO :0001934 and positive regulation of protein phosphorylation and biological process this GO :0002376 and immune system process and biological process this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0005080 and protein kinase C binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005654 and nucleoplasm and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005764 and lysosome and cellular component this GO :0005770 and late endosome and cellular component this GO :0005776 and autophagic vacuole and cellular component this GO :0005783 and endoplasmic reticulum and cellular component this GO :0005829 and cytosol and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006511 and ubiquitin-dependent protein catabolic process and biological process this GO :0006914 and autophagy and biological process this GO :0006950 and response to stress and biological process this GO :0008104 and protein localization and biological process this GO :0008270 and zinc ion binding and molecular function this GO :0016197 and endosomal transport and biological process this GO :0016234 and inclusion body and cellular component this GO :0016235 and aggresome and cellular component this GO :0016236 and macroautophagy and biological process this GO :0016239 and positive regulation of macroautophagy and biological process this GO :0016605 and PML body and cellular component this GO :0019901 and protein kinase binding and molecular function this GO :0030154 and cell differentiation and biological process this GO :0030971 and receptor tyrosine kinase binding and molecular function this GO :0031410 and cytoplasmic vesicle and cellular component this GO :0035556 and intracellular signal transduction and biological process this GO :0042169 and SH2 domain binding and molecular function this GO :0042802 and identical protein binding and molecular function this GO :0042803 and protein homodimerization activity and molecular function this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043122 and regulation of I-kappaB kinase/NF-kappaB signaling and biological process this GO :0043130 and ubiquitin binding and molecular function this GO :0045087 and innate immune response and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046578 and regulation of Ras protein signal transduction and biological process this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0051291 and protein heterooli this GO merization and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0070530 and K63-linked polyubiquitin binding and molecular function this GO :0097190 and apoptotic signaling pathway and biological process, this GO :0004674: protein serine/threonine kinase activity, this GO :0004674: protein serine/threonine kinase activity and also this GO :0005080: protein kinase C binding and also this GO :0005515: protein binding and also this GO :0008270: zinc ion binding and also this GO :0019901: protein kinase binding and also this GO :0030971: receptor tyrosine kinase binding and also this GO :0042169: SH2 domain binding and also this GO :0042802: identical protein binding and also this GO :0042803: protein homodimerization activity and also this GO :0043130: ubiquitin binding and also this GO :0070530: K63-linked polyubiquitin binding, this GO :0005080: protein kinase C binding, this GO :0005515: protein binding, this GO :0008270: zinc ion binding, this GO :0019901: protein kinase binding, this GO :0030971: receptor tyrosine kinase binding, this GO :0042169: SH2 domain binding, this GO :0042802: identical protein binding, this GO :0042803: protein homodimerization activity, this GO :0043130: ubiquitin binding, this GO :0070530: K63-linked polyubiquitin binding, 105440 and IDBG-640935 and ENSBTAG00000015591 and 338045, sequestosome 1 |
| Identity | 11280 |
| Gene | SQSTM1 |
| Long gene name | sequestosome 1 |
| Synonyms gene | PDB3 OSIL |
| Synonyms gene name | Paget disease of bone 3 oxidative stress induced like |
| Synonyms | p62 p60 p62B A170 |
| Locus | 5q35, 3 |
| Discovery year | 2000-06-13 |
| GenBank acession | U46751 |
| Entrez gene record | 8878 |
| Pubmed identfication | 8650207 8551575 |
| Classification | Zinc fingers ZZ-type |
| Havana BLAST/BLAT | OTTHUMG00000150643 |
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