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Src(Tyr529) Antibody

Src(Tyr529) Antibody size: 0.1ml 281

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 281
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameSrc(Tyr529) Primary Polyclonal Antibody
Also known asSrc(Tyr529) PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenSrc Tyr529
SpecificityThis is a highly specific antibody against Src Tyr529
Modification(s)Phosphorylation
Modification site(s)Tyr529
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceKLH conjugated synthetic phosphopeptide derived from mouse Src around the phosphorylation site of tyrosine 529
Gene ID number6714
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Full catalytic activity of Src requires phosphorylation of tyrosine 418, Immunogen: Synthetic peptide (Human) derived from the region of Src that contains tyrosine 529, Mutations in this gene could be involved in the malignant progression of colon cancer, Src is a proto oncogene that may play a role in the regulation of embryonic development and cell growth, The sequence is conserved in mouse (tyrosine 534), The tyrosine 418 is located in the catalytic domain and is one of the autophosphorylation sites, The tyrosine 529 is located near the carboxyl terminus of Src and acts as a negative regulator, There are two critical phosphorylation sites of tyrosine on Src, This conformation blocks phosphorylation of tyrosine 418 at the catalytic domain, When tyrosine 529 is dephosphorylated, based on the human sequence, chicken (tyrosine 527) and frog (tyrosine 525), in that Src is held in the inactive form through an intramolecular interaction between the SH2 domain and the carboxyl terminus when tyrosine 529 is phosphorylated by Csk, thereby preventing Src activation, tyrosine 418 and tyrosine 529 (referring to human Src sequence), tyrosine 418 can be maximally phosphorylated and Src becomes active, Src (also known as pp60src) is a non receptor Tyrosine Kinase involved in signal transduction in many biological systems and implicated in the development of human tumors
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names ASV, Avian sarcoma virus, CDNA FLJ14219 fis clone NT2RP3003800 highly similar to Rattus norvegicus tyrosine protein kinase pp60 c src mRNA, EC 2, Neuronal CSRC tyrosine specic protein kinase, Neuronal SRC, OTTHUMP00000030931, OTTHUMP00000174476, OTTHUMP00000174477, Oncogene SRC, Proto oncogene tyrosine protein kinase Src, Proto-oncogene c-Src, Proto-oncogene tyrosine-protein kinase Src, Protooncogene SRC, SRC Oncogene, SRC1, SRC_MOUSE, Src, Tyrosine kinase pp60c src, Tyrosine protein kinase SRC 1, Tyrosine protein kinase SRC1, V src sarcoma Schmidt Ruppin A 2 viral oncogene homolog avian, c SRC, cSrc, p60 Src, p60-Src, p60Src, pp60c src, pp60c-src, pp60csrc, protooncogene SRC Rous sarcoma, v src avian sarcoma Schmidt Ruppin A2 viral oncogene homolog, v src sarcoma Schmidt Ruppin A 2 viral oncogene homolog avian, vsrc avian sarcoma Schmidt Ruppin A2 viral oncogene homolog, 2, 7, 10, SrcTyr529
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetSrc(Tyr529)
Short nameSrc(Tyr529) Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative namev-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)(Tyr529) (Antibody to)
Alternative techniqueantibodies

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