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SUFU/Suppressor of Fused Antibody

SUFU/Suppressor of Fused Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameSUFU/Suppressor of Fused Antibody
Also known asSUFU/Suppressor of Fused Antibody
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenSUFU/Suppressor of Fused
SpecificityThis is a highly specific antibody against SUFU/Suppressor of Fused
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range440-484/484
Subcellular location Nucleus, Cytoplasm
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human SUFU
Gene ID number51684
Swiss ProtQ9UMX1
Tested Applications IF(IHC-P), IHC-P
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Down-regulates GLI1-mediated transactivation of target genes, GLI2 and GLI3 in the cytoplasm, GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state, May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome, Negative regulator of beta-catenin signaling, Part of a corepressor complex that acts on DNA-bound GLI1, Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full length form of GLI3 (GLI3FL), Required for the proper formation of hair follicles and the control of epidermal differentiation (By similarity), SUFU dissociates from GLI3FL and the latter translocates to the nucleus, Sequesters GLI1, When Hh signaling is initiated, Without the Hh signal, and converted to a transcriptional activator (GLI3A), destabilized, leading to the efficient processing of GLI3FL into GLI3R, the SUFU-GLI3 complex is recruited to cilia, this effect is overcome by binding of STK36 to both SUFU and a GLI protein, where it is phosphorylated, Negative regulator in the hedgehog signaling pathway
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names PRO1280, SUFU, SUFUXL, Suppressor of fused homolog, UNQ650/PRO1280, SUFUH
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Description HRAS like - suppressor protein make genetic suppression restoring the phenotype seen prior to the original background in , breast cancer tumor, Kinase, biological pathways
Gene targetSUFU/Suppressor of Fused
Short nameSUFU/Suppressor of Fused Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameSUFU/Suppressor on Fused (Antibody to)
Alternative techniqueantibodies
Identity 16466
Gene SUFU
Long gene name SUFU negative regulator of hedgehog signaling
Synonyms gene name suppressor of fused homolog (Drosophila)
Synonyms SUFUH SUFUXL PRO1280
Locus 10q24, 32
Discovery year 2001-08-28
GenBank acession AF175770
Entrez gene record 51684
Pubmed identfication 15367681
RefSeq identity NM_016169
Havana BLAST/BLAT OTTHUMG00000018966
Locus Specific Databases LRG_521

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